TNNC1 / Cardiac Troponin C, Monoclonal Antibody

Anti-TNNC1 / Cardiac Troponin C Antibody IHC-plus; TNNC1; CMD1Z; Cardiac troponin C; CMH13; Troponin C type 1 (slow); TN-C; TNNC; Troponin C; slow; Troponin C1; slow; Human TNNC1; Cardiac Troponin C

For Research Use Only. Not for use in diagnostic procedures.

Monoclonal

IgG2b

Mouse

Recognizes cardiac and skeletal troponin I. It is specific for an epitope between aa186-192 of cardiac troponin I. Species cross-reactivity: Mouse, Cat, Rabbit, Dog, Pig, Rat, Goat, Bovine, Fish.

Protein A Purified

PBS, pH 7.2, 0.09% sodium azide

1 mg/ml (lot specific)

May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months.

Small volumes of anti-TNNC1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Immunohistochemistry (IHC - Paraffin), Western Blot (WB), ELISA (EIA)

ELISA, IHC-P (10 ug/ml), WB
Usage: Suitable for use in ELISA and Western Blot.

Anti-TNNC1 antibody IHC of human skeletal muscle. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.

18,403 Da

troponin C type 1 (slow)

troponin C, slow skeletal and cardiac muscles; troponin C1, slow; cardiac troponin C; slow twitch skeletal/cardiac muscle troponin C

Troponin C, slow skeletal and cardiac muscles

TNNC; TN-C  [Similar Products]

TNNC1_HUMAN

Troponin is a central regulatory protein of striated muscle contraction, and together with tropomyosin, is located on the actin filament. Troponin consists of 3 subunits: TnI, which is the inhibitor of actomyosin ATPase; TnT, which contains the for tropomyosin; and TnC, the protein encoded by this gene. The binding of calcium to TnC abolishes the inhibitory action of TnI, thus allowing the interaction of actin with myosin, the hydrolysis of ATP, and the generation of tension. Mutations in this gene are associated with cardiomyopathy dilated type 1Z. [provided by RefSeq, Oct 2008]

TNNC1: Troponin is the central regulatory protein of striated muscle contraction. Tn consists of three components: Tn-I which is the inhibitor of actomyosin ATPase, Tn-T which contains the for tropomyosin and Tn-C. The binding of calcium to Tn-C abolishes the inhibitory action of Tn on actin filaments. Defects in TNNC1 are the cause of cardiomyopathy dilated type 1Z (CMD1Z). Dilated cardiomyopathy is a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death. Defects in TNNC1 are the cause of familial hypertrophic cardiomyopathy type 13 (CMH13). A hereditary heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. They can be readily provoked by exercise. The disorder has inter- and intrafamilial variability ranging from benign to malignant forms with high risk of cardiac failure and sudden cardiac death. Belongs to the troponin C family.

Protein type: Motility/polarity/chemotaxis; Calcium-binding

Chromosomal Location of Human Ortholog: 3p21.1

Cellular Component: nucleoplasm; troponin complex; mitochondrion; cytosol; actin cytoskeleton

Molecular Function: troponin T binding; actin filament binding; protein binding; protein homodimerization activity; troponin I binding; calcium ion binding; calcium-dependent protein binding

Biological Process: response to metal ion; regulation of ATPase activity; regulation of muscle contraction; diaphragm contraction; ventricular cardiac muscle morphogenesis; regulation of muscle filament sliding speed; muscle filament sliding; cardiac muscle contraction

Disease: Cardiomyopathy, Dilated, 1z; Cardiomyopathy, Familial Hypertrophic, 13

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