Product Name
Troponin C (TNNC1), Monoclonal Antibody
Full Product Name
Troponin C antibody (Cardiac)
Product Synonym Names
Monoclonal Troponin C (Cardiac); Anti-Troponin C (Cardiac)
Product Gene Name
anti-TNNC1 antibody
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Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P63316
Purity/Purification
Troponin C antibody (Cardiac) was purified by chromatography on protein A Sepharose.
Form/Format
Protein A purified IgG supplied in PBS, pH 7.4, 0.1 % NaN3.
Biological Significance
Troponin C is a part of the troponin complex. It contains four calcium-binding EF hands. It is a component of thin filaments (along with actin and tropomyosin). It contains an N lobe and a C lobe. The C lobe serves a structural purpose and binds to the N domain of TnI. The C lobe can bind either Ca2+ or Mg2+. The tissue specific subtypes are slow troponin C, and fast troponin C.
Biohazard Information
This product contains sodium azide as preservative. Although the amount of sodium azide is very small appropriate care must be taken when handling this product.
Immunogen
Troponin C antibody (cardiac) was raised in mouse using human TnC as the immunogen.
Preparation and Storage
Store at 4 degree C.
Other Notes
Small volumes of anti-TNNC1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-TNNC1 antibody
Mouse monoclonal Troponin C antibody (Cardiac)
Product Categories/Family for anti-TNNC1 antibody
Cardiac Markers
Applications Tested/Suitable for anti-TNNC1 antibody
ELISA (EIA), Western Blot (WB)
NCBI/Uniprot data below describe general gene information for TNNC1. It may not necessarily be applicable to this product.
NCBI Accession #
NP_003271.1
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NCBI GenBank Nucleotide #
NM_003280.2
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UniProt Primary Accession #
P63316
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UniProt Secondary Accession #
O14800; P02590; P04463[Other Products]
UniProt Related Accession #
P63316[Other Products]
Molecular Weight
18,403 Da[Similar Products]
NCBI Official Full Name
troponin C, slow skeletal and cardiac muscles
NCBI Official Synonym Full Names
troponin C type 1 (slow)
NCBI Official Symbol
TNNC1 [Similar Products]
NCBI Official Synonym Symbols
TNC; TN-C; TNNC; CMD1Z; CMH13
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NCBI Protein Information
troponin C, slow skeletal and cardiac muscles
UniProt Protein Name
Troponin C, slow skeletal and cardiac muscles
UniProt Gene Name
TNNC1 [Similar Products]
UniProt Synonym Gene Names
TNNC; TN-C [Similar Products]
UniProt Entry Name
TNNC1_HUMAN
NCBI Summary for TNNC1
Troponin is a central regulatory protein of striated muscle contraction, and together with tropomyosin, is located on the actin filament. Troponin consists of 3 subunits: TnI, which is the inhibitor of actomyosin ATPase; TnT, which contains the for tropomyosin; and TnC, the protein encoded by this gene. The binding of calcium to TnC abolishes the inhibitory action of TnI, thus allowing the interaction of actin with myosin, the hydrolysis of ATP, and the generation of tension. Mutations in this gene are associated with cardiomyopathy dilated type 1Z. [provided by RefSeq, Oct 2008]
UniProt Comments for TNNC1
TNNC1: Troponin is the central regulatory protein of striated muscle contraction. Tn consists of three components: Tn-I which is the inhibitor of actomyosin ATPase, Tn-T which contains the for tropomyosin and Tn-C. The binding of calcium to Tn-C abolishes the inhibitory action of Tn on actin filaments. Defects in TNNC1 are the cause of cardiomyopathy dilated type 1Z (CMD1Z). Dilated cardiomyopathy is a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death. Defects in TNNC1 are the cause of familial hypertrophic cardiomyopathy type 13 (CMH13). A hereditary heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. They can be readily provoked by exercise. The disorder has inter- and intrafamilial variability ranging from benign to malignant forms with high risk of cardiac failure and sudden cardiac death. Belongs to the troponin C family.
Protein type: Motility/polarity/chemotaxis; Calcium-binding
Chromosomal Location of Human Ortholog: 3p21.1
Cellular Component: nucleoplasm; troponin complex; mitochondrion; cytosol; actin cytoskeleton
Molecular Function: actin filament binding; troponin T binding; protein binding; protein homodimerization activity; troponin I binding; calcium ion binding; calcium-dependent protein binding
Biological Process: response to metal ion; regulation of ATPase activity; regulation of muscle contraction; diaphragm contraction; ventricular cardiac muscle morphogenesis; regulation of muscle filament sliding speed; cardiac muscle contraction; muscle filament sliding
Disease: Cardiomyopathy, Dilated, 1z; Cardiomyopathy, Familial Hypertrophic, 13
Research Articles on TNNC1
1. in vitro characterisation of six cardiac Troponin C mutations causing hypertrophic and dilated cardiomyopathies (Review)
Precautions
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Disclaimer
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