Troponin C, ELISA Kit

Troponin C; slow skeletal and cardiac muscles; TN-C; TNNC1; TNNC

For Research Use Only. Not for use in diagnostic procedures.

Store at 4 degree C

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Small volumes of TNNC1 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS9427504 is a ready-to-use microwell, strip-or-full plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Troponin C (TNNC1) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing TNNC1. The ELISA analytical biochemical technique of the MBS9427504 kit is based on TNNC1 antibody-TNNC1 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect TNNC1 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, TNNC1. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).

18,403 Da

troponin C1, slow skeletal and cardiac type

troponin C, slow skeletal and cardiac muscles

Troponin C, slow skeletal and cardiac muscles

TNNC; TN-C  [Similar Products]

Troponin is a central regulatory protein of striated muscle contraction, and together with tropomyosin, is located on the actin filament. Troponin consists of 3 subunits: TnI, which is the inhibitor of actomyosin ATPase; TnT, which contains the for tropomyosin; and TnC, the protein encoded by this gene. The binding of calcium to TnC abolishes the inhibitory action of TnI, thus allowing the interaction of actin with myosin, the hydrolysis of ATP, and the generation of tension. Mutations in this gene are associated with cardiomyopathy dilated type 1Z. [provided by RefSeq, Oct 2008]

TNNC1: Troponin is the central regulatory protein of striated muscle contraction. Tn consists of three components: Tn-I which is the inhibitor of actomyosin ATPase, Tn-T which contains the for tropomyosin and Tn-C. The binding of calcium to Tn-C abolishes the inhibitory action of Tn on actin filaments. Defects in TNNC1 are the cause of cardiomyopathy dilated type 1Z (CMD1Z). Dilated cardiomyopathy is a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death. Defects in TNNC1 are the cause of familial hypertrophic cardiomyopathy type 13 (CMH13). A hereditary heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. They can be readily provoked by exercise. The disorder has inter- and intrafamilial variability ranging from benign to malignant forms with high risk of cardiac failure and sudden cardiac death. Belongs to the troponin C family.

Protein type: Calcium-binding; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 3p21.1

Cellular Component: cytosol; troponin complex

Molecular Function: actin filament binding; calcium ion binding; calcium-dependent protein binding; protein binding; protein homodimerization activity; troponin I binding; troponin T binding

Biological Process: cardiac muscle contraction; muscle filament sliding; regulation of ATPase activity; regulation of muscle contraction; regulation of muscle filament sliding speed; skeletal muscle contraction; ventricular cardiac muscle morphogenesis

Disease: Cardiomyopathy, Dilated, 1z; Cardiomyopathy, Familial Hypertrophic, 13

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