Sodium-Dependent Phosphate Transport Protein 2B (SLC34A2), ELISA Kit

For Research Use Only. Not for use in diagnostic procedures.

Store all reagents at 2-8 degree C

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Small volumes of SLC34A2 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS9907821 is a ready-to-use microwell, strip-or-full plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Sodium-Dependent Phosphate Transport Protein 2B (SLC34A2) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing SLC34A2. The ELISA analytical biochemical technique of the MBS9907821 kit is based on SLC34A2 antibody-SLC34A2 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect SLC34A2 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, SLC34A2. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).

75,657 Da

solute carrier family 34 member 2

sodium-dependent phosphate transport protein 2B

Sodium-dependent phosphate transport protein 2B

Sodium-phosphate transport protein 2B; Na(+)/Pi cotransporter 2B; NaPi-2b  [Similar Products]

The protein encoded by this gene is a pH-sensitive sodium-dependent phosphate transporter. Phosphate uptake is increased at lower pH. Defects in this gene are a cause of pulmonary alveolar microlithiasis. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, May 2010]

SLC34A2: May be involved in actively transporting phosphate into cells via Na(+) cotransport. It may be the main phosphate transport protein in the intestinal brush border membrane. May have a role in the synthesis of surfactant in lungs' alveoli. Defects in SLC34A2 are a cause of pulmonary alveolar microlithiasis (PALM). Pulmonary alveolar microlithiasis is a rare disease characterized by the deposition of calcium phosphate microliths throughout the lungs. Most patients are asymptomatic for several years or even for decades and generally, the diagnosis is incidental to clinical investigations unrelated to the disease. Cases with early onset or rapid progression are rare. A 'sandstorm-appearing' chest roentgenogram is a typical diagnostic finding. The onset of this potentially lethal disease varies from the neonatal period to old age and the disease follows a long-term, progressive course, resulting in a slow deterioration of lung functions. Pulmonary alveolar microlithiasis is a recessive monogenic disease with full penetrance. A chromosomal aberration involving SLC34A2 is found in a non-small cell lung cancer cell line. Results in the formation of a SLC34A2-ROS1 chimeric protein that retains a constitutive kinase activity. Belongs to the SLC34A transporter family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family

Chromosomal Location of Human Ortholog: 4p15.2

Cellular Component: apical plasma membrane; brush border; brush border membrane; cytoplasm; integral component of membrane; integral component of plasma membrane; plasma membrane; vesicle

Molecular Function: phosphate binding; sodium ion binding; sodium-dependent phosphate transmembrane transporter activity; sodium:phosphate symporter activity

Biological Process: cellular phosphate ion homeostasis; cellular protein metabolic process; in utero embryonic development; phosphate ion transport; response to estrogen; sodium-dependent phosphate transport

Disease: Pulmonary Alveolar Microlithiasis; Testicular Microlithiasis

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