Product Name
5-hydroxytryptamine receptor 6 (HTR6), Recombinant Protein
Full Product Name
Recombinant Human 5-hydroxytryptamine receptor 6 (HTR6)
Product Gene Name
HTR6 recombinant protein
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence Positions
1-440aa; Full length protein
Sequence
MVPEPGPTAN STPAWGAGPP SAPGGSGWVA AALCVVIALT AAANSLLIAL ICTQPALRNT SNFFLVSLFT SDLMVGLVVM PPAMLNALYG RWVLARGLCL LWTAFDVMCC SASILNLCLI SLDRYLLILS PLRYKLRMTP LRALALVLGA WSLAALASFL PLLLGWHELG HARPPVPGQC RLLASLPFVL VASGLTFFLP SGAICFTYCR ILLAARKQAV QVASLTTGMA SQASETLQVP RTPRPGVESA DSRRLATKHS RKALKASLTL GILLGMFFVT WLPFFVANIV QAVCDCISPG LFDVLTWLGY CNSTMNPIIY PLFMRDFKRA LGRFLPCPRC PRERQASLAS PSLRTSHSGP RPGLSLQQVL PLPLPPDSDS DSDAGSGGSS GLRLTAQLLL PGEATQDPPL PTRAAAAVNF FNIDPAEPEL RPHPLGIPTN
3D Structure
ModBase 3D Structure for P50406
Host
Cell Free Expression
Form/Format
Liquid containing glycerol
Storage Buffer
Tris-based buffer, 50% glycerol.
Preparation and Storage
Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.
Repeated freezing and thawing is not recommended. Store working aliquots at 4 degree C for up to one week.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of HTR6 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Product Categories/Family for HTR6 recombinant protein
Transmembrane Protein
Application Notes for HTR6 recombinant protein
This is a recombinant transmembrane protein expressed in a cell-free expression system.
NCBI/Uniprot data below describe general gene information for HTR6. It may not necessarily be applicable to this product.
NCBI Accession #
NP_000862.1
[Other Products]
NCBI GenBank Nucleotide #
NM_000871.2
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UniProt Primary Accession #
P50406
[Other Products]
UniProt Secondary Accession #
Q13640; Q5TGZ1[Other Products]
UniProt Related Accession #
P50406[Other Products]
Molecular Weight
46,954 Da
NCBI Official Full Name
5-hydroxytryptamine receptor 6
NCBI Official Synonym Full Names
5-hydroxytryptamine receptor 6
NCBI Official Symbol
HTR6 [Similar Products]
NCBI Official Synonym Symbols
5-HT6; 5-HT6R
[Similar Products]
NCBI Protein Information
5-hydroxytryptamine receptor 6
UniProt Protein Name
5-hydroxytryptamine receptor 6
UniProt Synonym Protein Names
Serotonin receptor 6
Protein Family
5-hydroxytryptamine receptor
UniProt Gene Name
HTR6 [Similar Products]
UniProt Synonym Gene Names
5-HT-6; 5-HT6 [Similar Products]
UniProt Entry Name
5HT6R_HUMAN
NCBI Summary for HTR6
This gene encodes a protein that belongs to the seven-transmembrane G protein-coupled receptor family of proteins. The encoded protein couples with the Gs alpha subunit and stimulates adenylate cyclase to activate the cyclic AMP-dependent signaling pathway. This receptor is thought to regulate cholinergic neuronal transmission in the brain. Several antidepressants and antipsychotic drugs have a high affinity for this receptor. [provided by RefSeq, Aug 2013]
UniProt Comments for HTR6
5-HT(6): This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase. It has a high affinity for tricyclic psychotropic drugs. Belongs to the G-protein coupled receptor 1 family.
Protein type: Membrane protein, multi-pass; Receptor, GPCR; GPCR, family 1; Membrane protein, integral
Chromosomal Location of Human Ortholog: 1p36-p35
Cellular Component: cilium; integral to plasma membrane; plasma membrane
Molecular Function: histamine receptor activity; protein binding; serotonin receptor activity
Biological Process: cerebral cortex cell migration; G-protein signaling, coupled to cyclic nucleotide second messenger; positive regulation of TOR signaling pathway; serotonin receptor signaling pathway; synaptic transmission
Research Articles on HTR6
1. that HTR6 plays an important role in modulating seizure activity and that the blockade of the 5-HT6 receptor/mTOR pathway could be a potential therapeutic target for epilepsy treatment
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
