SALL1, Polyclonal Antibody

Goat Anti-SALL1 Antibody; SALL1; sal-like 1 (Drosophila); HSAL1; TBS; ZNF794; sal-like 1; spalt-like transcription factor 1; SALL1 antibody; sal-like 1 (Drosophila) antibody; HSAL1 antibody; TBS antibody; ZNF794 antibody; sal-like 1 antibody; spalt-like transcription factor 1 antibody; SALL1 (aa29-43)

For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

Goat

Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.

Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.

100ug specific antibody in 200ul (lot specific)

Aliquot and store at -20 degree C. Minimize freezing and thawing.

Manufactured in an ISO 9001:2008 Certified Laboratory.

Small volumes of anti-SALL1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Peptide ELISA (EIA)

Peptide ELISA: Antibody detection limit dilution 1: 32000.

129,571 Da

spalt-like transcription factor 1

sal-like protein 1

Sal-like protein 1

SAL1; ZNF794; HSal1; Sal-1  [Similar Products]

SALL1_HUMAN

The protein encoded by this gene is a zinc finger transcriptional repressor and may be part of the NuRD histone deacetylase complex (HDAC). Defects in this gene are a cause of Townes-Brocks syndrome (TBS) as well as bronchio-oto-renal syndrome (BOR). Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

SALL1: Transcriptional repressor involved in organogenesis. Defects in SALL1 are the cause of Townes-Brocks syndrome (TBS). TBS is a rare, autosomal dominant malformation syndrome with a combination of imperforate anus, triphalangeal and supernumerary thumbs, malformed ears and sensorineural hearing loss. Some individuals with SALL1 mutations manifest a phenotype overlapping with TBS and bronchio-oto-renal syndrome. Clinical features include dysplastic ears, hypoplastic kidneys with impaired renal function, gastroesophageal reflux, hypermetropia, hypospadias, and mild developmental delay. Affected individuals lack the characteristic anal or hand malformations of TBS. Belongs to the sal C2H2-type zinc-finger protein family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Transcription factor; C2H2-type zinc finger protein

Chromosomal Location of Human Ortholog: 16q12.1

Cellular Component: chromocenter; cytoplasm; heterochromatin; nucleoplasm; nucleus; NuRD complex

Molecular Function: beta-catenin binding; DNA binding; histone deacetylase activity; metal ion binding; protein binding; sequence-specific DNA binding; transcription factor activity

Biological Process: adrenal gland development; embryonic digit morphogenesis; embryonic gut development; gonad development; heart development; histone deacetylation; inductive cell-cell signaling; kidney development; limb development; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; neurogenesis; olfactory bulb interneuron differentiation; olfactory nerve development; outer ear morphogenesis; pituitary gland development; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; positive regulation of Wnt receptor signaling pathway; somatic stem cell maintenance; transcription, DNA-dependent; ureteric bud branching; ureteric bud development

Disease: Townes-brocks Syndrome

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