ASPSCR1, Polyclonal Antibody

ASPSCR1 antibody

For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

Rabbit

Purified by immunoaffinity chromatography.

Supplied in liquid form in PBS buffer (no MG2+ or Ca2+), pH 7.4, 150 mm NaCl, 0.02% sodium azide and 50% glycerol.

1 mg/ml (lot specific)

Store at 4 degree C for short term storage. Aliquot and store at -20 degree C for long term storage. Avoid repeated freeze/thaw cycles.

Small volumes of anti-ASPSCR1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Cancer

Western Blot (WB)

WB: 1:500-1:1000

Western Blot analysis of extracts from HL60 cells using ASPSCR1 antibody

37,910 Da

ASPSCR1, UBX domain containing tether for SLC2A4

tether containing UBX domain for GLUT4

Tether containing UBX domain for GLUT4

ASPL; RCC17; TUG; UBXD9; UBXN9  [Similar Products]

The protein encoded by this gene contains a UBX domain and interacts with glucose transporter type 4 (GLUT4). This protein is a tether, which sequesters the GLUT4 in intracellular vesicles in muscle and fat cells in the absence of insulin, and redistributes the GLUT4 to the plasma membrane within minutes of insulin stimulation. Translocation t(X;17)(p11;q25) of this gene with transcription factor TFE3 gene results in a ASPSCR1-TFE3 fusion protein in alveolar soft part sarcoma and in renal cell carcinomas. Multiple alternatively spliced transcript variants have been found. [provided by RefSeq, Oct 2011]

ASPSCR1: Tethering protein that sequesters GLUT4-containing vesicles in the cytoplasm in the absence of insulin. Modulates the amount of GLUT4 that is available at the cell surface. Interacts with GLUT4. Ubiquitous. Highly expressed in testis, heart, skeletal muscle and pancreas. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, peripheral; Oncoprotein; Vesicle

Chromosomal Location of Human Ortholog: 17q25.3

Cellular Component: intracellular membrane-bound organelle; nucleoplasm; plasma membrane

Molecular Function: protein binding

Disease: Alveolar Soft Part Sarcoma

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