Product Name
SLC22A5, Polyclonal Antibody
Full Product Name
SLC22A5 Antibody
Product Gene Name
anti-SLC22A5 antibody
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Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for O76082
Specificity
SLC22A5 Antibody detects endogenous levels of SLC22A5.
Purity/Purification
Purified from rabbit antiserum by affinity-chromatography using immunogen.
Form/Format
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration
1 mg/ml (lot specific)
Target Modification
Unmodified/Total
Immunogen
The antiserum was produced against synthesized peptide derived from human SLC22A5.
Preparation and Storage
Stable at -20 degree C for at least 1 year.
Other Notes
Small volumes of anti-SLC22A5 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-SLC22A5 antibody
Western Blot (WB), ELISA (EIA)
Application Notes for anti-SLC22A5 antibody
WB: 1:500~1:1000
ELISA: 1:10000
Western Blot (WB) of anti-SLC22A5 antibody
Western blot analysis of the lysates from HeLa cells using SLC22A5 antibody.
NCBI/Uniprot data below describe general gene information for SLC22A5. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001295051.1
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NCBI GenBank Nucleotide #
NM_001308122.1
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UniProt Primary Accession #
O76082
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UniProt Secondary Accession #
Q6ZQZ8; Q96EH6; A2Q0V1; B2R844; D3DQ87[Other Products]
UniProt Related Accession #
O76082[Other Products]
NCBI Official Full Name
solute carrier family 22 member 5 isoform a
NCBI Official Synonym Full Names
solute carrier family 22 member 5
NCBI Official Symbol
SLC22A5 [Similar Products]
NCBI Official Synonym Symbols
CDSP; OCTN2
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NCBI Protein Information
solute carrier family 22 member 5
UniProt Protein Name
Solute carrier family 22 member 5
UniProt Synonym Protein Names
High-affinity sodium-dependent carnitine cotransporter; Organic cation/carnitine transporter 2
Protein Family
Solute carrier family
UniProt Gene Name
SLC22A5 [Similar Products]
UniProt Synonym Gene Names
OCTN2 [Similar Products]
NCBI Summary for SLC22A5
Polyspecific organic cation transporters in the liver, kidney, intestine, and other organs are critical for elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins. The encoded protein is a plasma integral membrane protein which functions both as an organic cation transporter and as a sodium-dependent high affinity carnitine transporter. The encoded protein is involved in the active cellular uptake of carnitine. Mutations in this gene are the cause of systemic primary carnitine deficiency (CDSP), an autosomal recessive disorder manifested early in life by hypoketotic hypoglycemia and acute metabolic decompensation, and later in life by skeletal myopathy or cardiomyopathy. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Apr 2015]
UniProt Comments for SLC22A5
Sodium-ion dependent, high affinity carnitine transporter. Involved in the active cellular uptake of carnitine. Transports one sodium ion with one molecule of carnitine. Also transports organic cations such as tetraethylammonium (TEA) without the involvement of sodium. Also relative uptake activity ratio of carnitine to TEA is 11.3.
Research Articles on SLC22A5
1. The OCTN2 carnitine transporter is essential for retaining carnitine in the body and allowing adequate supplies to the heart and the skeletal muscle, which derive most of their energy from fat. Mutations impairing its function result in carnitine deficiency that can present early in life with hypoketotic hypoglycemia, or later in life with cardiomyopathy and sudden death from cardiac arrhythmia. Review.
Precautions
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Disclaimer
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