Product Name
Lamin A (lmna), Monoclonal Antibody
Popular Item
Full Product Name
Mouse Anti-Lamin A [JOL4]
Product Synonym Names
70 kDa lamin antibody; CDCD1 antibody; CDDC antibody; CMD1A antibody; CMT2B1 antibody; EMD2antibody; FPL antibody; FPLD antibody; HGPS antibody; IDC antibody; LAMIN A antibody; lamin A/Cantibody; LAMIN C antibody; Lamin-A/C antibody; LDP1 antibody; LFP antibody; LGMD1B antibody; LMN 1antibody; LMN A antibody; LMN C antibody; LMN1 antibody; LMNA antibody; LMNA_HUMAN antibody; LMNC antibody; NYREN 32 antigen antibody; PRO1 antibody; Renal carcinoma antigen NY-REN-32 antibody
Product Gene Name
anti-lmna antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P11048
Species Reactivity
Human, Mouse
Specificity
The antibody reacts with both recombinant and native lamin A in humans, binding to an epitope between amino acids 572-646
Purity/Purification
Unpurified
Form/Format
Tissue culture supernatant containing 0.2M Tris/HCl pH7.4 and 510% foetal calf serum;
Immunogen
Recombinant human lamin A
Myeloma/fusion Partners
Spleen cells from immunised BALB/c mice were fused with cells of the mouse SP20/Ag4 myeloma cell line;
Research Areas
Cell Biology; Class V Lamins; Cytoskeleton; Cytoskeleton / ECM; Intermediate Filaments; Lamins; Nuclear Envelope; Nucleus; Subcellular Markers; Tags Cell Markers
Other Notes
Small volumes of anti-lmna antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-lmna antibody
Immunofluorescence (IF), Immunohistochemistry (IHC) Formalin, Immunoprecipitation (IP), Western Blot (WB)
Application Notes for anti-lmna antibody
Optimal antibody dilution should be determined by titration, however as a guideline try; IP: Use neat. WB: 1/50. Predicted molecular weight: 74 kDa.
Immunofluorescence/Immunocytochemistry (IF/ICC) of anti-lmna antibody
NCBI/Uniprot data below describe general gene information for lmna. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001095210.1
[Other Products]
NCBI GenBank Nucleotide #
NM_001101740.1
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UniProt Primary Accession #
P11048
[Other Products]
UniProt Related Accession #
P11048; AAB23219[Other Products]
Molecular Weight
74,919 Da[Similar Products]
NCBI Official Full Name
lamin-A
NCBI Official Synonym Full Names
lamin A/C<
NCBI Official Symbol
lmna [Similar Products]
NCBI Official Synonym Symbols
lmna-A
[Similar Products]
NCBI Protein Information
lamin-A
UniProt Protein Name
Lamin-A
UniProt Gene Name
lmna [Similar Products]
UniProt Entry Name
LMNA_XENLA
UniProt Comments for lmna
Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin.
Product References and Citations for anti-lmna antibody
Both emerin and lamin C depend on lamin A for localization at the nuclear envelope. Vaughan A (J Cell Sci,Jul 2001)PUBMED
Research Articles on lmna
1. These results indicate that thyroid hormone-regulated expression of nuclear lamin A and LIII closely correlates with dedifferentiation of the epithelial cells in the X. laevis intestine.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
