Product Name
Lamin A/B (lmna), Polyclonal Antibody
Full Product Name
Lamin A/B antibody (Ser392)
Product Synonym Names
Polyclonal Lamin A/B; Anti-Lamin A/B; lamin A; lamin A/B; lamin B; Lamin-A/B; Lmn1; Lmna
Product Gene Name
anti-lmna antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Species Reactivity
Mouse, Rat - Reactive with proteins phosphorylated as follows: Human: Ser392, Mouse: Ser392, Rat: Ser392
Specificity
Lamin A/B antibody (Ser392) detects endogenous levels of Lamin A/B (lamin A/C) only when phosphorylated at serine 392
Purity/Purification
Lamin A/B antibody was purified by affinity chromatography
Form/Format
Supplied in liquid format, PBS buffer, pH 7.4, 150mM NaCl with added preservative 0.02% sodium azide and 50% glycerol
Concentration
1 mg/ml (lot specific)
Biological Significance
Lamins are intermediate filament proteins that constitute the lattice-like matrix at the inner face of the nuclear membrane that underlies the nuclear envelop.
Immunogen
Lamin A/B antibody was raised in Rabbit using a synthesized phosphopeptide derived from human Lamin A/B (lamin A/C) around the phosphorylation site of serine 392 (S-P-SP-P-T) as the immunogen
Preparation and Storage
Aliquot and store at -20 degree C. Avoid repeated freeze thaw cycles
Other Notes
Small volumes of anti-lmna antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-lmna antibody
Rabbit polyclonal Lamin A/B antibody (Ser392)
Product Categories/Family for anti-lmna antibody
Cell Biology; Purified Polyclonal Antibodies
Applications Tested/Suitable for anti-lmna antibody
ELISA (EIA), Immunohistochemistry (IHC), Immunofluorescence (IF), Western Blot (WB)
Application Notes for anti-lmna antibody
WB: 1:500 - 1:1000
IHC: 1:50 - 1:100
IF: 1:100 - 1:500
ELISA: 1:1000
Immunohistochemistry (IHC) of anti-lmna antibody
Immunohistochemistry analysis of paraffin-embedded human breast carcinoma tissue using Lamin A/B (Phospho-Ser392) antibody.
Immunofluorescence (IF) of anti-lmna antibody
Western Blot (WB) of anti-lmna antibody
Western blot analysis of extracts from HeLa cells, using Lamin A/B (Phospho-Ser392) antibody.
NCBI/Uniprot data below describe general gene information for lmna. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001095210.1
[Other Products]
NCBI GenBank Nucleotide #
NM_001101740.1
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UniProt Related Accession #
P11048; AAB23219[Other Products]
Molecular Weight
74,919 Da[Similar Products]
NCBI Official Full Name
lamin-A
NCBI Official Synonym Full Names
lamin A/C<
NCBI Official Symbol
lmna [Similar Products]
NCBI Official Synonym Symbols
lmna-A
[Similar Products]
NCBI Protein Information
lamin-A
UniProt Protein Name
Lamin-A
UniProt Gene Name
lmna [Similar Products]
UniProt Entry Name
LMNA_XENLA
UniProt Comments for lmna
Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin.
Research Articles on lmna
1. These results indicate that thyroid hormone-regulated expression of nuclear lamin A and LIII closely correlates with dedifferentiation of the epithelial cells in the X. laevis intestine.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
