CTNNA3, Monoclonal Antibody

Anti -CTNNA3 (Catenin alpha-3, Alpha T-catenin, Cadherin-associated Protein)

For Research Use Only. Not for use in diagnostic procedures.

Chromosome: 10; NC_000010.10 (67672276..69455949, complement). Location: 10q22.2

Monoclonal

IgG1,k

3F4-1B11

Mouse

Recognizes human CTNNA3.

Affinity Purified
Purified by Protein A affinity chromatography.

Supplied as a liquid in PBS, pH 7.2.

May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Small volumes of anti-CTNNA3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Alpha-catenins stabilize the cell-cell contacts by functioning as a molecular switch that regulates actin dynamics at the site of the adherens junction. Alpha-T Catenin is involved in the formation of stretch-resistant cell-cell adhesion complexes. Alpha-T catenin is expressed predominantly in cardiomyocytes, where it colocalizes with alpha-E catenin at the intercalated discs. Moreover, alpha-T Catenin is also expressed in the brain and inhibits Wnt signaling, so it is implicated in Alzheimer's disease.

Antibodies; Abs to Catenin

ELISA (EL/EIA), Western Blot (WB)

Suitable for use in ELISA and Western Blot.

99,809 Da[Similar Products]

catenin (cadherin-associated protein), alpha 3

catenin alpha-3; alpha T-catenin; alpha-T-catenin; alpha-catenin-like protein; cadherin-associated protein

Catenin alpha-3

CTNA3_HUMAN

This gene encodes a protein that belongs to the vinculin/alpha-catenin family. The encoded protein plays a role in cell-cell adhesion in muscle cells. Mutations in this gene are associated with arrhythmogenic right ventricular dysplasia, familial 13. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]

CTNNA3: May be involved in formation of stretch-resistant cell- cell adhesion complexes. Belongs to the vinculin/alpha-catenin family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Cell adhesion

Chromosomal Location of Human Ortholog: 10q22.2

Cellular Component: cytoskeleton; lamellipodium; cytoplasm; fascia adherens

Molecular Function: actin filament binding; protein binding; cadherin binding

Biological Process: cell-cell adhesion

Disease: Arrhythmogenic Right Ventricular Dysplasia, Familial, 13

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