Alpha Synuclein, Polyclonal Antibody

Rabbit Anti-Human Alpha Synuclein Polyclonal; Alpha Synuclein Antibody; Non-A4 component of amyloid precursor Antibody; MGC105443 Antibody; OTTHUMP00000218552 Antibody; MGC110988 Antibody; OTTHUMP00000218553 Antibody; Synuclein alpha 140 Antibody; alphaSYN Antibody; Parkinson disease familial 1 Antibody; OTTHUMP00000218554 Antibody; Parkinson disease (autosomal dominant; Lewy body) 4 Antibody; Synuclein; alpha (non A4 component of amyloid precursor) Antibody; OTTHUMP00000218549 Antibody; Non A4 component of amyloid precursor Antibody; MGC127560 Antibody; SYN Antibody; SNCA Antibody; MGC64356 Antibody; Non A4 component of amyloid Antibody; PARK4 Antibody; Alpha synuclein Antibody; PARK 1 Antibody; Snca synuclein; Synuclein alpha Antibody; Non-A4 component of amyloid; precursor of Antibody; OTTHUMP00000218551 Antibody; PARK 4 Antibody; PARK1 Antibody; Alpha-synuclein; isoform NACP140 Antibody; Non-A-beta component of alzheimers disease amyloid; Non-A beta component of AD amyloid Antibody; NACP Antibody; SYUA_HUMAN Antibody; Alpha-synuclein Antibody; Non A beta component of AD amyloid Antibody

For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

Rabbit

Detects ~14.46kda. Highly expressed in brain (presynaptic nerve terminals) but is also expressed in low concentrations in all tissues examined except in liver.

Protein A Purified

PBS pH 7.4, 50% glycerol, 0.09% Sodium Azide

1 mg/ml (lot specific)

Store at-20 degree C.

Small volumes of anti-SNCA antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Alpha-Synuclein (SNCA) is expressed predominantly in the brain, where it is concentrated in presynaptic nerve terminals (1). Alpha-synuclein is highly expressed in the mitochondria of the olfactory bulb, hippocampus, striatum and thalamus (2). Functionally, it has been shown to significantly interact with tubulin (3), and may serve as a potential microtubule-associated protein. It has also been found to be essential for normal development of the cognitive functions; inactivation may lead to impaired spatial learning and working memory (4). SNCA fibrillar aggregates represent the major non A-beta component of Alzheimers disease amyloid plaque, and a major component of Lewy body inclusions, and Parkinson's disease. Parkinson's disease (PD) is a common neurodegenerative disorder characterized by the progressive accumulation in selected neurons of protein inclusions containing alpha-synuclein and ubiquitin (5, 6).

Neuroscience; Neurodegeneration; Alzheimer's Disease; Tangles & Tau; Neuroscience; Neurodegeneration; Parkinson's Disease; Synuclein

Western Blot (WB), ELISA (EIA)

WB: 1:1000

Western blot analysis of Mouse Brain showing detection of ~14.46kDa Alpha Synuclein protein using Rabbit Anti-Alpha Synuclein Polyclonal Antibody . Lane 1: Molecular Weight Ladder (MW). Lane 2: Mouse Brain. Load: 15 ug. Block: 5% Skim Milk powder in TBST. Primary Antibody: Rabbit Anti-Alpha Synuclein Polyclonal Antibody at 1:1000 for 2 hours at RT with shaking. Secondary Antibody: Goat anti-rabbit IgG:HRP at 1:4000 for 1 hour at RT with shaking. Color Development: Chemiluminescent for HRP (Moss) for 5 min in RT. Predicted/Observed Size: ~14.46kDa. Other Band(s): Higher molecular weight oligomers.

synuclein alpha

alpha-synuclein

Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and alpha- and beta-synuclein inhibit phospholipase D2 selectively. SNCA may serve to integrate presynaptic signaling and membrane trafficking. Defects in SNCA have been implicated in the pathogenesis of Parkinson disease. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. Alternatively spliced transcripts encoding different isoforms have been identified for this gene. [provided by RefSeq, Feb 2016]

1. "Genetics Home Reference: SNCA". US National Library of Medicine. (2013). 2. Zhang L., et al. (2008) Brain Res. 1244: 40-52. 3. Alim M.A., et al. (2002) J Biol Chem. 277(3): 2112-2117. 4. Kokhan V.S., Afanasyeva M.A., Van'kin G. (2012) Behav. Brain. Res. 231(1): 226-230. 5. Spillantini M.G., et al. (1997) Nature. 388(6645): 839-840. 6. Mezey E., et al. (1998) Nat Med. 4(7): 755-757.

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