ABLIM1, Polyclonal Antibody

ABLIM; LIMAB1; LIMATIN; abLIM-1

For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

IgG

Rabbit

Antigen affinity purification

1.1mg/mL (lot specific)

Store at -20 degree C (regular) and -80 degree C (long term). Avoid freeze / thaw cycles.

Manufactured in an ISO 9001:2015 Certified Laboratory.

Small volumes of anti-ABLIM1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

This gene encodes a cytoskeletal LIM protein that binds to actin filaments via a domain that is homologous to erythrocyte dematin. LIM domains, found in over 60 proteins, play key roles in the regulation of developmental pathways. LIM domains also function as protein-binding interfaces, mediating specific protein-protein interactions. The protein encoded by this gene could mediate such interactions between actin filaments and cytoplasmic targets. Alternatively spliced transcript variants encoding different isoforms have been identified.

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)

WB: 1:500-1:2000
IHC: 1:15-1:50

Western Blot analysis of Mouse heart tissue using ABLIM1 Polyclonal Antibody at dilution of 1:550

Immunohistochemistry of paraffin-embedded Human esophagus cancer using ABLIM1 Polyclonal Antibody at dilution of 1:25

84,559 Da

actin binding LIM protein 1

actin-binding LIM protein 1; actin-binding LIM protein family member 1; actin-binding double-zinc-finger protein

Actin-binding LIM protein 1

ABLIM; KIAA0059; LIMAB1; abLIM-1  [Similar Products]

ABLM1_HUMAN

This gene encodes a cytoskeletal LIM protein that binds to actin filaments via a domain that is homologous to erythrocyte dematin. LIM domains, found in over 60 proteins, play key roles in the regulation of developmental pathways. LIM domains also function as protein-binding interfaces, mediating specific protein-protein interactions. The protein encoded by this gene could mediate such interactions between actin filaments and cytoplasmic targets. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

abLIM: a cytoskeletal LIM protein consisting of a C-terminal cytoskeletal domain fused to an N-terminal domain of four double zinc finger motifs. The C-terminal domain is 50% identical to dematin, an actin-bundling protein of the erythroid cytoskeleton. Undergoes extensive phosphorylation in light-adapted retinas in vivo and its developmental expression in the retina coincides with the elaboration of photoreceptor inner and outer segments. Three distinct splice variant isoforms have been described: ABLIM-l, ABLIM-m, ABLIM-s.

Protein type: Actin-binding; Motility/polarity/chemotaxis; Cytoskeletal

Chromosomal Location of Human Ortholog: 10q25

Cellular Component: lamellipodium; cytoplasm; stress fiber; actin cytoskeleton

Molecular Function: protein binding; zinc ion binding; actin binding

Biological Process: lamellipodium biogenesis; axon guidance; organ morphogenesis; visual perception; cilium biogenesis; cytoskeleton organization and biogenesis; positive regulation of transcription from RNA polymerase II promoter

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