Product Name
RPS24, cDNA Clone
Product Synonym Names
DBA3; S24
Product Gene Name
RPS24 cdna clone
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Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence
Nucleotide Sequence: ATGAACGACA CCGTAACTAT CCGCACTAGA AAGTTCATGA CCAACCGACT ACTTCAGAGG AAACAAATGG TCATTGATGT CCTTCACCCC GGGAAGGCGA CAGTGCCTAA GACAGAAATT CGGGAAAAAC TAGCCAAAAT GTACAAGACC ACACCGGATG TCATCTTTGT ATTTGGATTC AGAACTCATT TTGGTGGTGG CAAGACAACT GGCTTTGGCA TGATTTATGA TTCCCTGGAT TATGCAAAGA AAAATGAACC CAAACATAGA CTTGCAAGAC ATGGCCTGTA TGAGAAGAAA AAGACCTCAA GAAAGCAACG AAAGGAACGC AAGAACAGAA TGAAGAAAGT CAGGGGGACT GCAAAGGCCA ATGTTGGTGC TGGCAAAAAG TGA
Translati on Sequence: MNDTVTIRTR KFMTNRLLQR KQMVIDVLHP GKATVPKTEI REKLAKMYKT TPDVIFVFGF RTHFGGGKTT GFGMIYDSLD YAKKNEPKHR LARHGLYEKK KTSRKQRKER KNRMKKVRGT AKANVGAGKK
3D Structure
ModBase 3D Structure for P62847
Chromosome Location
10q22
OMIM Reference Number
602412
Vector Description
This shuttle vector contains the complete ORF. It is inseted BamH I to Xho I. The gene insert contains multiple cloning sites which can be used to easily cut and transfer the gene and recombination site into your expression vector.
Vector
(puc19-derived cloning vector)
Preparation Before Usage
1. Centrifuge at 7000rpm for 1 minute. 2. Carefully open the vial and add 100ul of sterile water to dissolve the DNA. Each tube contains approximately 10ug of lyophilized plasmid.
Preparation and Storage
Store the plasmid at -20 degree C.
Other Notes
Small volumes of RPS24 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
RPS24 cdna clone
40S ribosomal protein S24 isoform a, also known as RPS24, belongs to the S24E family of ribosomal proteins. It is located in the cytoplasm. Multiple transcript variants encoding different isoforms have been found for this gene. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. Mutations in this gene result in Diamond-Blackfan anemia.
Product Categories/Family for RPS24 cdna clone
Epigenomics (Transcription & Translation)
NCBI/Uniprot data below describe general gene information for RPS24. It may not necessarily be applicable to this product.
NCBI Accession #
NP_148982.1
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NCBI GenBank Nucleotide #
NM_033022.3
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UniProt Primary Accession #
P62847
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UniProt Related Accession #
P62847[Other Products]
NCBI Official Full Name
40S ribosomal protein S24 isoform a
NCBI Official Synonym Full Names
ribosomal protein S24
NCBI Official Symbol
RPS24 [Similar Products]
NCBI Official Synonym Symbols
S24; DBA3; eS24
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NCBI Protein Information
40S ribosomal protein S24
UniProt Protein Name
40S ribosomal protein S24
Protein Family
40S ribosomal protein
UniProt Gene Name
RPS24 [Similar Products]
UniProt Entry Name
RS24_HUMAN
NCBI Summary for RPS24
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S24E family of ribosomal proteins. It is located in the cytoplasm. Multiple transcript variants encoding different isoforms have been found for this gene. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. Mutations in this gene result in Diamond-Blackfan anemia. [provided by RefSeq, Nov 2008]
UniProt Comments for RPS24
RPS24: Required for processing of pre-rRNA and maturation of 40S ribosomal subunits. Defects in RPS24 are the cause of Diamond-Blackfan anemia type 3 (DBA3). DBA3 is a form of Diamond-Blackfan anemia, a congenital non-regenerative hypoplastic anemia that usually presents early in infancy. Diamond-Blackfan anemia is characterized by a moderate to severe macrocytic anemia, erythroblastopenia, and an increased risk of malignancy. 30 to 40% of Diamond-Blackfan anemia patients present with short stature and congenital anomalies, the most frequent being craniofacial (Pierre-Robin syndrome and cleft palate), thumb and urogenital anomalies. Belongs to the ribosomal protein S24e family. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: RNA-binding; Translation; Ribosomal
Chromosomal Location of Human Ortholog: 10q22
Cellular Component: small ribosomal subunit; membrane; cytoplasm; nucleolus; nucleus; cytosol
Molecular Function: structural constituent of ribosome; translation initiation factor binding; nucleotide binding
Biological Process: SRP-dependent cotranslational protein targeting to membrane; viral reproduction; translation; viral infectious cycle; translational termination; ribosomal small subunit biogenesis and assembly; erythrocyte homeostasis; maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); cellular protein metabolic process; translational elongation; translational initiation; mRNA catabolic process, nonsense-mediated decay; gene expression; viral transcription; rRNA processing
Disease: Diamond-blackfan Anemia 3
Research Articles on RPS24
1. The results show that RPS19, RPS21 or RPS24 are upregulated in malignant tissue and may serve as putative biomarkers for prostate cancer.
Precautions
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Disclaimer
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