CYCS / Cytochrome c, Monoclonal Antibody

Anti-CYCS / Cytochrome c Antibody (clone 7H8) IHC-plus; CYCS; CYC; HCS; THC4; Cytochrome c; Cytochrome c; somatic; Human CYCS; Cytochrome c

For Research Use Only. Not for use in diagnostic procedures.

Monoclonal

IgG2b,k

7H8

Mouse

Affinity Purified

PBS, pH 7.2, 150 mM sodium chloride, 0.09% sodium azide

Store at 4 degree C, avoid repeated freeze thaw cycles.

Small volumes of anti-CYCS antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Immunohistochemistry (IHC - Paraffin), Western Blot (WB)

IHC-P (20 ug/ml), WB
Usage: The 7H8 antibody has been tested for western blotting on cell lysates prepared from Hela and Jurkat cell lines. This antibody can be used at 1-10 ug/ml. It is recommended that the reagent be carefully titrated for optimal performance in the assay of...

Anti-Cytochrome c antibody IHC of human breast. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 20 ug/ml.

Anti-Cytochrome c antibody IHC of human heart. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 20 ug/ml.

Western Blot of cell lysates prepared from HeLa (lane 1) and Jurkat (lane 2) cell lines under reducing conditions using 5 ug/mL anti-cytochrome c antibody. Bands were visualized using HRP-conjugated rat anti-mouse IgG.

11,749 Da

cytochrome c, somatic

cytochrome c

Cytochrome c

CYC  [Similar Products]

CYC_HUMAN

This gene encodes a small heme protein that functions as a central component of the electron transport chain in mitochondria. The encoded protein associates with the inner membrane of the mitochondrion where it accepts electrons from cytochrome b and transfers them to the cytochrome oxidase complex. This protein is also involved in initiation of apoptosis. Mutations in this gene are associated with autosomal dominant nonsyndromic thrombocytopenia. Numerous processed pseudogenes of this gene are found throughout the human genome.[provided by RefSeq, Jul 2010]

CYCS: Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. Belongs to the cytochrome c family.

Protein type: Protein phosphatase, Ser/Thr (non-receptor); Oxidoreductase; Mitochondrial; Apoptosis

Chromosomal Location of Human Ortholog: 7p15.3

Cellular Component: protein phosphatase type 2A complex; mitochondrion; mitochondrial inner membrane; mitochondrial intermembrane space; nucleus; cytosol

Molecular Function: electron transporter, transferring electrons from CoQH2-cytochrome c reductase complex and cytochrome c oxidase complex activity; protein binding; iron ion binding; heme binding; protein serine/threonine phosphatase activity

Biological Process: mitochondrion organization and biogenesis; cellular metabolic process; response to reactive oxygen species; dephosphorylation; apoptosis; organelle organization and biogenesis; cellular respiration; mitochondrial electron transport, cytochrome c to oxygen; caspase activation via cytochrome c; DNA fragmentation during apoptosis; transmembrane transport; mitochondrial electron transport, ubiquinol to cytochrome c

Disease: Thrombocytopenia 4

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