Product Name
Cytokine-dependent hematopoietic cell linker (CLNK), Recombinant Protein
Full Product Name
Recombinant Human Cytokine-dependent hematopoietic cell linker (CLNK)
Product Gene Name
CLNK recombinant protein
[Similar Products]
Product Synonym Gene Name
CLNK[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence Positions
1-428aa, full length protein
Sequence
MNRQGNRKTT KEGSNDLKFQ NFSLPKNRSW PRINSATGQY QRMNKPLLDW ERNFAAVLDG AKGHSDDDYD DPELRMEETW QSIKILPARP IKESEYADTH YFKVAMDTPL PLDTRTSISI GQPTWNTQTR LERVDKPISK DVRSQNIKGD ASVRKNKIPL PPPRPLITLP KKYQPLPPEP ESSRPPLSQR HTFPEVQRMP SQISLRDLSE VLEAEKVPHN QRKPESTHLL ENQNTQEIPL AISSSSFTTS NHSVQNRDHR GGMQPCSPQR CQPPASCSPH ENILPYKYTS WRPPFPKRSD RKDVQHNEWY IGEYSRQAVE EAFMKENKDG SFLVRDCSTK SKEEPYVLAV FYENKVYNVK IRFLERNQQF ALGTGLRGDE KFDSVEDIIE HYKNFPIILI DGKDKTGVHR KQCHLTQPLP LTRHLLPL
3D Structure
ModBase 3D Structure for Q7Z7G1
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Purity/Purification
>85% (SDS-PAGE) (lot specific)
Form/Format
Liquid containing glycerol
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
Storage Buffer
Tris-based buffer, 50% glycerol
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of CLNK recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for CLNK. It may not necessarily be applicable to this product.
NCBI Accession #
NP_443196.2
[Other Products]
NCBI GenBank Nucleotide #
NM_052964.3
[Other Products]
UniProt Primary Accession #
Q7Z7G1
[Other Products]
UniProt Secondary Accession #
Q05C27; Q9P2U9[Other Products]
UniProt Related Accession #
Q7Z7G1[Other Products]
Molecular Weight
45,469 Da
NCBI Official Full Name
cytokine-dependent hematopoietic cell linker
NCBI Official Synonym Full Names
cytokine dependent hematopoietic cell linker
NCBI Official Symbol
CLNK [Similar Products]
NCBI Official Synonym Symbols
MIST
[Similar Products]
NCBI Protein Information
cytokine-dependent hematopoietic cell linker
UniProt Protein Name
Cytokine-dependent hematopoietic cell linker
UniProt Synonym Protein Names
Mast cell immunoreceptor signal transducer
Protein Family
Cytokine-dependent hematopoietic cell linker
UniProt Gene Name
CLNK [Similar Products]
UniProt Synonym Gene Names
MIST [Similar Products]
NCBI Summary for CLNK
MIST is a member of the SLP76 family of adaptors (see LCP2, MIM 601603; BLNK, MIM 604515). MIST plays a role in the regulation of immunoreceptor signaling, including PLC-gamma (PLCG1; MIM 172420)-mediated B cell antigen receptor (BCR) signaling and FC-epsilon R1 (see FCER1A, MIM 147140)-mediated mast cell degranulation (Cao et al., 1999 [PubMed 10562326]; Goitsuka et al., 2000, 2001 [PubMed 10744659] [PubMed 11463797]).[supplied by OMIM, Mar 2008]
UniProt Comments for CLNK
Plays a role in the regulation of immunoreceptor signaling, including PLC-gamma-mediated B-cell antigen receptor (BCR) signaling and FC-epsilon R1-mediated mast cell degranulation. Involved in phosphorylation of LAT ().
Research Articles on CLNK
1. Identify positive correlations between WDR1 and CLNK gene polymorphisms in Chinese-Tibetan gout populations.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
