Full Product Name
AQP3 Polyclonal Antibody
Product Synonym Names
GIL; AQP-3
Product Gene Name
anti-AQP3 antibody
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Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q92482
Immunogen
Recombinant protein of human AQP3
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Preparation and Storage
Store at -20 degree C. Avoid freeze/thaw cycles.
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Other Notes
Small volumes of anti-AQP3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-AQP3 antibody
This gene encodes the water channel protein aquaporin 3. Aquaporins are a family of small integral membrane proteins related to the major intrinsic protein, also known as aquaporin 0. Aquaporin 3 is localized at the basal lateral membranes of collecting duct cells in the kidney. In addition to its water channel function, aquaporin 3 has been found to facilitate the transport of nonionic small solutes such as urea and glycerol, but to a smaller degree. It has been suggested that water channels can be functionally heterogeneous and possess water and solute permeation mechanisms.
Applications Tested/Suitable for anti-AQP3 antibody
Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-AQP3 antibody
WB: 1:500-1:2000
IHC: 1:50-1:200
NCBI/Uniprot data below describe general gene information for AQP3. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001305073.1
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NCBI GenBank Nucleotide #
NM_001318144.1
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UniProt Primary Accession #
Q92482
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UniProt Secondary Accession #
O00108; Q6FGT2; Q6FGW6; A8K843; B2RE16; D3DRL3[Other Products]
UniProt Related Accession #
Q92482[Other Products]
NCBI Official Full Name
aquaporin-3 isoform 2
NCBI Official Synonym Full Names
aquaporin 3 (Gill blood group)
NCBI Official Symbol
AQP3 [Similar Products]
NCBI Official Synonym Symbols
GIL; AQP-3
[Similar Products]
NCBI Protein Information
aquaporin-3
UniProt Protein Name
Aquaporin-3
UniProt Synonym Protein Names
Aquaglyceroporin-3
UniProt Gene Name
AQP3 [Similar Products]
UniProt Synonym Gene Names
AQP-3 [Similar Products]
NCBI Summary for AQP3
This gene encodes the water channel protein aquaporin 3. Aquaporins are a family of small integral membrane proteins related to the major intrinsic protein, also known as aquaporin 0. Aquaporin 3 is localized at the basal lateral membranes of collecting duct cells in the kidney. In addition to its water channel function, aquaporin 3 has been found to facilitate the transport of nonionic small solutes such as urea and glycerol, but to a smaller degree. It has been suggested that water channels can be functionally heterogeneous and possess water and solute permeation mechanisms. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015]
UniProt Comments for AQP3
AQP3: Water channel required to promote glycerol permeability and water transport across cell membranes. Acts as a glycerol transporter in skin and plays an important role in regulating SC (stratum corneum) and epidermal glycerol content. Involved in skin hydration, wound healing, and tumorigenesis. Provides kidney medullary collecting duct with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient. Slightly permeable to urea and may function as a water and urea exit mechanism in antidiuresis in collecting duct cells. It may play an important role in gastrointestinal tract water transport and in glycerol metabolism. Belongs to the MIP/aquaporin (TC 1.A.8) family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Channel, misc.; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, aquaporin family
Chromosomal Location of Human Ortholog: 9p13.3
Cellular Component: cytoplasm; integral to membrane; intercellular junction; nucleus; plasma membrane
Molecular Function: glycerol channel activity; water channel activity
Biological Process: excretion; odontogenesis; positive regulation of immune system process; regulation of keratinocyte differentiation; renal water homeostasis; response to calcium ion; response to retinoic acid; response to vitamin D; water transport
Disease: Gil Blood Group
Research Articles on AQP3
1. RNA interference (RNAi) of aquaporin 3 (AQP3) retarded the growth and invasiveness of XWLC-05 lung cancer cells and decreased the activity of matrix metalloproteinase 2 (MMP2).
Precautions
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Disclaimer
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