Product Name
3-ketodihydrosphingosine reductase (KDSR), Recombinant Protein
Full Product Name
Recombinant Human 3-ketodihydrosphingosine reductase (KDSR)
Product Gene Name
KDSR recombinant protein
[Similar Products]
Product Synonym Gene Name
FVT1[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence Positions
26-332aa; Full length protein
Sequence
KPLALPGAHV VVTGGSSGIG KCIAIECYKQ GAFITLVARN EDKLLQAKKE IEMHSINDKQ VVLCISVDVS QDYNQVENVI KQAQEKLGPV DMLVNCAGMA VSGKFEDLEV STFERLMSIN YLGSVYPSRA VITTMKERRV GRIVFVSSQA GQLGLFGFTA YSASKFAIRG LAEALQMEVK PYNVYITVAY PPDTDTPGFA EENRTKPLET RLISETTSVC KPEQVAKQIV KDAIQGNFNS SLGSDGYMLS ALTCGMAPVT SITEGLQQVV TMGLFRTIAL FYLGSFDSIV RRCMMQREKS ENADKTA
3D Structure
ModBase 3D Structure for Q06136
Host
Cell Free Expression
Form/Format
Liquid containing glycerol
Storage Buffer
Tris-based buffer, 50% glycerol.
Preparation and Storage
Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.
Repeated freezing and thawing is not recommended. Store working aliquots at 4 degree C for up to one week.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of KDSR recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Product Categories/Family for KDSR recombinant protein
Transmembrane Protein
Application Notes for KDSR recombinant protein
This is a recombinant transmembrane protein expressed in a cell-free expression system.
NCBI/Uniprot data below describe general gene information for KDSR. It may not necessarily be applicable to this product.
NCBI Accession #
NP_002026.1
[Other Products]
NCBI GenBank Nucleotide #
NM_002035.2
[Other Products]
UniProt Primary Accession #
Q06136
[Other Products]
UniProt Secondary Accession #
B2R5Y1; B4DMX0[Other Products]
UniProt Related Accession #
Q06136[Other Products]
Molecular Weight
29,159 Da
NCBI Official Full Name
3-ketodihydrosphingosine reductase
NCBI Official Synonym Full Names
3-ketodihydrosphingosine reductase
NCBI Official Symbol
KDSR [Similar Products]
NCBI Official Synonym Symbols
DHSR; FVT1; SDR35C1
[Similar Products]
NCBI Protein Information
3-ketodihydrosphingosine reductase
UniProt Protein Name
3-ketodihydrosphingosine reductase
UniProt Synonym Protein Names
3-dehydrosphinganine reductase; Follicular variant translocation protein 1; FVT-1; Short chain dehydrogenase/reductase family 35C member 1
UniProt Gene Name
KDSR [Similar Products]
UniProt Synonym Gene Names
FVT1; SDR35C1; KDS reductase; FVT-1 [Similar Products]
UniProt Entry Name
KDSR_HUMAN
NCBI Summary for KDSR
The protein encoded by this gene catalyzes the reduction of 3-ketodihydrosphingosine to dihydrosphingosine. The putative active site residues of the encoded protein are found on the cytosolic side of the endoplasmic reticulum membrane. A chromosomal rearrangement involving this gene is a cause of follicular lymphoma, also known as type II chronic lymphatic leukemia. The mutation of a conserved residue in the bovine ortholog causes spinal muscular atrophy. [provided by RefSeq, Jul 2008]
UniProt Comments for KDSR
FVT1: Catalyzes the reduction of 3-ketodihydrosphingosine (KDS) to dihydrosphingosine (DHS). A chromosomal aberration involving KDSR is a cause of follicular lymphoma; also known as type II chronic lymphatic leukemia. Translocation t(2;18)(p11;q21) with a Ig J kappa chain region. Belongs to the short-chain dehydrogenases/reductases (SDR) family.
Protein type: Oxidoreductase; Lipid Metabolism - sphingolipid; Oncoprotein; EC 1.1.1.102; Membrane protein, multi-pass; Membrane protein, integral
Chromosomal Location of Human Ortholog: 18q21.3
Cellular Component: endoplasmic reticulum; endoplasmic reticulum membrane; extracellular space; integral to membrane; membrane
Molecular Function: 3-dehydrosphinganine reductase activity
Biological Process: 3-keto-sphinganine metabolic process; sphingolipid biosynthetic process
Research Articles on KDSR
1. FVT1 is significantly underexpressed by germinal center-type diffuse large B-cell lymphoma compared with non-germinal center-type DLBCL, follicular lymphoma, & normal tonsil control samples. Increased expression of FVT1 correlated with decreased survival.
Precautions
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Disclaimer
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