CLINT1, Polyclonal Antibody

For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

Rabbit

Affinity purified

Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

For short term use, store at 2-8 degree C up to 1 week. For long term storage, store at -20 degree C in small aliquots to prevent freeze-thaw cycles.

Small volumes of anti-CLINT1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

This gene encodes a protein with similarity to the epsin family of endocytic adapter proteins. The encoded protein interacts with clathrin, the adapter protein AP-1 and phosphoinositides. This protein may be involved in the formation of clathrin coated vesicles and trafficking between the trans-Golgi network and endosomes. Mutations in this gene are associated with a susceptibility to schizophrenia and psychotic disorders. Alternate splicing results in multiple transcript variants.

Polyclonal; Membrane & Traffic; Disease Related; DNA/RNA/Protein Interactions;

Western Blot (WB)

Host: Rabbit
Target Name: CLINT1
Sample Tissue: Human Mesenchymoma Tumor lysates
Antibody Dilution: 1ug/ml

643 kDa

clathrin interactor 1

clathrin interactor 1

Clathrin interactor 1

ENTH; EPN4; EPNR; KIAA0171; Clint; EpsinR  [Similar Products]

EPN4_HUMAN

This gene encodes a protein with similarity to the epsin family of endocytic adapter proteins. The encoded protein interacts with clathrin, the adapter protein AP-1 and phosphoinositides. This protein may be involved in the formation of clathrin coated vesicles and trafficking between the trans-Golgi network and endosomes. Mutations in this gene are associated with a susceptibility to schizophrenia and psychotic disorders. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2010]

ENTH: Binds to membranes enriched in phosphatidylinositol 4,5- bisphosphate (PtdIns(4,5)P2). May have a role in transport via clathrin-coated vesicles from the trans-Golgi network to endosomes. Stimulates clathrin assembly. Belongs to the epsin family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Motility/polarity/chemotaxis; Adaptor/scaffold

Chromosomal Location of Human Ortholog: 5q33.3

Cellular Component: nucleoplasm; Golgi apparatus; intracellular membrane-bound organelle; membrane; clathrin-coated vesicle; perinuclear region of cytoplasm; cytosol

Molecular Function: protein binding; clathrin binding; lipid binding

Biological Process: clathrin cage assembly; endocytosis; post-Golgi vesicle-mediated transport

Disease: Schizophrenia 1

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