Full Product Name
Alas1 Antibody
Product Gene Name
anti-Alas1 antibody
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Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P13196
Other Notes
Small volumes of anti-Alas1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Western Blot (WB) of anti-Alas1 antibody
Western blot analysis Alas1 using HUVEC whole cell lysates
NCBI/Uniprot data below describe general gene information for Alas1. It may not necessarily be applicable to this product.
NCBI Accession #
NP_000679.1
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NCBI GenBank Nucleotide #
NM_000688.5
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UniProt Primary Accession #
P13196
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UniProt Related Accession #
P13196[Other Products]
Molecular Weight
12,961 Da
NCBI Official Full Name
5-aminolevulinate synthase, nonspecific, mitochondrial isoform 1
NCBI Official Synonym Full Names
5'-aminolevulinate synthase 1
NCBI Official Symbol
ALAS1 [Similar Products]
NCBI Official Synonym Symbols
ALAS; MIG4; ALAS3; ALASH; ALAS-H
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NCBI Protein Information
5-aminolevulinate synthase, nonspecific, mitochondrial
UniProt Protein Name
5-aminolevulinate synthase, nonspecific, mitochondrial
UniProt Synonym Protein Names
5-aminolevulinic acid synthase 1; Delta-ALA synthase 1; Delta-aminolevulinate synthase 1
Protein Family
Alanine--tRNA ligase
UniProt Gene Name
ALAS1 [Similar Products]
UniProt Synonym Gene Names
ALAS3; ALASH; ALAS-H [Similar Products]
NCBI Summary for Alas1
This gene encodes the mitochondrial enzyme which is catalyzes the rate-limiting step in heme (iron-protoporphyrin) biosynthesis. The enzyme encoded by this gene is the housekeeping enzyme; a separate gene encodes a form of the enzyme that is specific for erythroid tissue. The level of the mature encoded protein is regulated by heme: high levels of heme down-regulate the mature enzyme in mitochondria while low heme levels up-regulate. A pseudogene of this gene is located on chromosome 12. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2015]
UniProt Comments for Alas1
MiscellaneousThere are two delta-ALA synthases in vertebrates: an erythroid- specific form and one (housekeeping) which is expressed in all tissues.
Research Articles on Alas1
1. the heme- in the N-terminal region of the mature ALAS1 protein is also necessary for the heme-dependent oxidation of ALAS1.
Precautions
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Disclaimer
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