Product Name
BDNF/NT-3 growth factors receptor (Ntrk2), Recombinant Protein
Full Product Name
BDNF/NT-3 growth factors receptor
Product Gene Name
Ntrk2 recombinant protein
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Sequence Positions
32-821aa; full length protein
Sequence
CPTSCKCSSA RIWCTEPSPG IVAFPRLEPN SVDPENITEI LIANQKRLEI INEDDVEAYV GLRNLTIVDS GLKFVAYKAF LKNSNLRHIN FTRNKLTSLS RRHFRHLDLS DLILTGNPFT CSCDIMWLKT LQETKSSPDT QDLYCLNESS KNMPLANLQI PNCGLPSARL AAPNLTVEEG KSVTLSCSVG GDPLPTLYWD VGNLVSKHMN ETSHTQGSLR ITNISSDDSG KQISCVAENL VGEDQDSVNL TVHFAPTITF LESPTSDHHW CIPFTVRGNP KPALQWFYNG AILNESKYIC TKIHVTNHTE YHGCLQLDNP THMNNGDYTL MAKNEYGKDE RQISAHFMGR PGVDYETNPN YPEVLYEDWT TPTDIGDTTN KSNEIPSTDV ADQSNREHLS VYAVVVIASV VGFCLLVMLL LLKLARHSKF GMKGPASVIS NDDDSASPLH HISNGSNTPS SSEGGPDAVI IGMTKIPVIE NPQYFGITNS QLKPDTFVQH IKRHNIVLKR ELGEGAFGKV FLAECYNLCP EQDKILVAVK TLKDASDNAR KDFHREAELL TNLQHEHIVK FYGVCVEGDP LIMVFEYMKH GDLNKFLRAH GPDAVLMAEG NPPTELTQSQ MLHIAQQIAA GMVYLASQHF VHRDLATRNC LVGENLLVKI GDFGMSRDVY STDYYRVGGH TMLPIRWMPP ESIMYRKFTT ESDVWSLGVV LWEIFTYGKQ PWYQLSNNEV IECITQGRVL QRPRTCPQEV YELMLGCWQR EPHTRKNIKS IHTLLQNLAK ASPVYLDILG
3D Structure
ModBase 3D Structure for P15209
Host
Cell Free Expression
Form/Format
Liquid containing glycerol
Species
Mus musculus (Mouse)
Storage Buffer
Tris-based buffer, 50% glycerol.
Preparation and Storage
Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.
Repeated freezing and thawing is not recommended. Store working aliquots at 4 degree C for up to one week.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of Ntrk2 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
Ntrk2 recombinant protein
This is a recombinant transmembrane protein expressed in a cell-free expression system.
Product Categories/Family for Ntrk2 recombinant protein
Transmembrane Protein
NCBI/Uniprot data below describe general gene information for Ntrk2. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001020245.1
[Other Products]
NCBI GenBank Nucleotide #
NM_001025074.2
[Other Products]
UniProt Primary Accession #
P15209
[Other Products]
UniProt Secondary Accession #
Q3TUF9; Q80WU0; Q91XJ9[Other Products]
UniProt Related Accession #
P15209[Other Products]
Molecular Weight
83,744 Da
NCBI Official Full Name
BDNF/NT-3 growth factors receptor isoform a
NCBI Official Synonym Full Names
neurotrophic tyrosine kinase, receptor, type 2
NCBI Official Symbol
Ntrk2 [Similar Products]
NCBI Official Synonym Symbols
Tkrb; trkB; trk-B; GP145-TrkB/GP95-TrkB
[Similar Products]
NCBI Protein Information
BDNF/NT-3 growth factors receptor
UniProt Protein Name
BDNF/NT-3 growth factors receptor
UniProt Synonym Protein Names
GP145-TrkB/GP95-TrkB; Trk-B; Neurotrophic tyrosine kinase receptor type 2; TrkB tyrosine kinase
Protein Family
BDNF/NT-3 growth factors receptor
UniProt Gene Name
Ntrk2 [Similar Products]
UniProt Synonym Gene Names
Trkb; Trk-B [Similar Products]
UniProt Entry Name
NTRK2_MOUSE
UniProt Comments for Ntrk2
TrkB: a receptor tyrosine kinase of the Trk family. Receptor for brain-derived neurotrophic factor (BDNF), neurotrophin-3, -4 and -5 but not nerve growth factor (NGF). Involved in the development and maintenance of the nervous system. Three splice variant isoforms have been described.
Protein type: Membrane protein, integral; Protein kinase, TK; Kinase, protein; EC 2.7.10.1; Protein kinase, tyrosine (receptor); TK group; Trk family
Cellular Component: axon; cell soma; cell surface; cytoplasm; cytosol; dendrite; dendritic spine; endosome; excitatory synapse; growth cone; integral to plasma membrane; nerve terminal; perikaryon; plasma membrane; postsynaptic density; postsynaptic membrane; presynaptic active zone; receptor complex; rough endoplasmic reticulum; terminal button
Molecular Function: brain-derived neurotrophic factor binding; brain-derived neurotrophic factor receptor activity; neurotrophin binding; neurotrophin receptor activity; protein binding; protein homodimerization activity; receptor tyrosine kinase binding; transmembrane receptor protein tyrosine kinase activity
Biological Process: brain-derived neurotrophic factor receptor signaling pathway; central nervous system neuron development; cerebral cortex development; feeding behavior; glutamate secretion; learning; long-term memory; mechanoreceptor differentiation; negative regulation of neuron apoptosis; neuromuscular junction development; neuron differentiation; neuron migration; oligodendrocyte differentiation; peripheral nervous system neuron development; positive regulation of axonogenesis; positive regulation of cell proliferation; positive regulation of MAPKKK cascade; positive regulation of peptidyl-serine phosphorylation; positive regulation of phosphoinositide 3-kinase cascade; positive regulation of synaptic transmission, glutamatergic; positive regulation of synaptogenesis; protein amino acid autophosphorylation; regulation of dendrite development; regulation of GTPase activity; regulation of MAPKKK cascade; regulation of metabolic process; regulation of neurotransmitter secretion; regulation of protein kinase B signaling cascade; retina development in camera-type eye; retinal rod cell development; vasculogenesis
Research Articles on Ntrk2
1. Brain-derived neurotrophic factor (BDNF) and its specific receptor, tropomyosin-related kinase (TrkB), have a role the in pathophysiology of depression.
Precautions
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Disclaimer
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