Product Name
MC4 Receptor, Polyclonal Antibody
Full Product Name
MC4 Receptor Antibody
Product Synonym Names
MC4 R; Melanocortin receptor 4; MGC126851; MGC138197 antibody
Product Gene Name
anti-MC4 antibody
[Similar Products]
Matching Pairs
Antibody: MC4 Receptor (MBS540872)
Positive Control: MC4 Receptor (MBS542949)
Antibody/Peptide Pairs
MC4 Receptor peptide (MBS543977) is used for blocking the activity of MC4 Receptor antibody (MBS540872)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P32245
Species Reactivity
Human, Mouse, Rat
Form/Format
Affinity Purified
Concentration
0.55-0.75 ug/ul in antibody stabilization buffer (lot specific)
Immunogen
Synthetic peptide taken within amino acid region 10-60 on human MC4R protein.
Expression
Brain, placental, and gut tissues.
Molecular Function
Melanocortin receptor activity, melanocyte-stimulating hormone receptor activity, neuropeptide binding, ubiquitin protein ligase binding
Subcellular Location
cell membrane, multi-pass membrane protein, membrane raft. (Note: Localizes to membrane rafts but is also loated in the cell membrane outside of these regions where channel response to cold is enhanced compared to membrane rafts).
Preparation and Storage
-20 degree C for long term storage
Other Notes
Small volumes of anti-MC4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-MC4 antibody
Affinity Purified Melanocortin receptor 4 Antibody
Receptor specific to the heptapeptide core common to adrenocorticotropic hormone and alpha-, beta-, and gamma-MSH. Plays a central role in energy homeostasis and somatic growth. This receptor is mediated by G proteins that stimulate adenylate cyclase (cAMP).
Product Categories/Family for anti-MC4 antibody
Primary Antibodies; Signal Transduction; G-Protein Coupled Receptors; MC4 Receptor Antibody
Applications Tested/Suitable for anti-MC4 antibody
ELISA (EIA), Immunohistochemistry (IHC), Immunoprecipitation (IP), Western Blot (WB)
Application Notes for anti-MC4 antibody
Dot Blot: 1:10,000
ELISA: 1:10,000
Immunohistochemistry: 1:100
Immunoprecipitation: 1:200
Western Blot: 1:500
Immunohistochemistry (IHC) of anti-MC4 antibody
NCBI/Uniprot data below describe general gene information for MC4. It may not necessarily be applicable to this product.
NCBI Accession #
NP_005903.2
[Other Products]
NCBI GenBank Nucleotide #
NM_005912.2
[Other Products]
UniProt Primary Accession #
P32245
[Other Products]
UniProt Secondary Accession #
Q16317; Q3MIJ6; B2RAC3[Other Products]
UniProt Related Accession #
P32245[Other Products]
Molecular Weight
36,943 Da
NCBI Official Full Name
melanocortin receptor 4
NCBI Official Synonym Full Names
melanocortin 4 receptor
NCBI Official Symbol
MC4R [Similar Products]
NCBI Protein Information
melanocortin receptor 4
UniProt Protein Name
Melanocortin receptor 4
UniProt Gene Name
MC4R [Similar Products]
UniProt Synonym Gene Names
MC4-R [Similar Products]
UniProt Entry Name
MC4R_HUMAN
NCBI Summary for MC4
The protein encoded by this gene is a membrane-bound receptor and member of the melanocortin receptor family. The encoded protein interacts with adrenocorticotropic and MSH hormones and is mediated by G proteins. This is an intronless gene. Defects in this gene are a cause of autosomal dominant obesity. [provided by RefSeq, Jan 2010]
UniProt Comments for MC4
MC4R: receptor specific to the heptapeptide core common to adrenocorticotropic hormone and alpha-, beta-, and gamma-MSH. A G-protein coupled receptor that stimulates adenylate cyclase. Defects are a cause of autosomal dominant obesity
Protein type: Membrane protein, multi-pass; Membrane protein, integral; Receptor, GPCR; GPCR, family 1
Chromosomal Location of Human Ortholog: 18q22
Cellular Component: integral to membrane; nucleus; plasma membrane
Molecular Function: melanocortin receptor activity; melanocyte stimulating hormone receptor activity; neuropeptide binding; peptide hormone binding; protein binding; ubiquitin protein ligase binding
Biological Process: diet induced thermogenesis; energy reserve metabolic process; feeding behavior; G-protein signaling, coupled to cAMP nucleotide second messenger; insulin secretion; positive regulation of bone resorption; positive regulation of cAMP biosynthetic process; response to insulin stimulus
Disease: Obesity
Research Articles on MC4
1. Drawing on recent advances in neuroscience and genetic technologies, we consider the structure and function of the melanocortin-4 receptor circuitry and its role in energy homeostasis--{REVIEW}
Precautions
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Disclaimer
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