PAX3, Monoclonal Antibody

Anti-PAX3 Antibody (C-Terminus, clone C2) IHC-plus; PAX3; CDHS; Paired domain gene 3; Paired box protein Pax-3; Paired domain gene HuP2; Waardenburg syndrome 1; WS1; HUP2; Paired box 3; Paired box homeotic gene 3; WS3; Quail PAX3

For Research Use Only. Not for use in diagnostic procedures.

Monoclonal

IgG2a

C2

Mouse

Protein G Purified

PBS, pH 7.2, 0.09% azide, 50% glycerol

1 mg/ml (lot specific)

Store at -20 degree C.

Small volumes of anti-PAX3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Immunohistochemistry (IHC - Paraffin), Western Blot (WB)

IHC-P (10 ug/ml), WB
Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary anti...

Anti-PAX3 antibody IHC of human skeletal muscle. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.

Anti-PAX3 antibody IHC of human skin. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.

 

55,975 Da

paired box 3

paired box protein Pax-3; paired domain gene 3; paired domain gene HuP2; paired box homeotic gene 3

Paired box protein Pax-3

HUP2  [Similar Products]

PAX3_HUMAN

This gene is a member of the paired box (PAX) family of transcription factors. Members of the PAX family typically contain a paired box domain and a paired-type homeodomain. These genes play critical roles during fetal development. Mutations in paired box gene 3 are associated with Waardenburg syndrome, craniofacial-deafness-hand syndrome, and alveolar rhabdomyosarcoma. The translocation t(2;13)(q35;q14), which represents a fusion between PAX3 and the forkhead gene, is a frequent finding in alveolar rhabdomyosarcoma. Alternative splicing results in transcripts encoding isoforms with different C-termini. [provided by RefSeq, Jul 2008]

PAX3: Probable transcription factor associated with development of alveolar rhabdomyosarcoma. Can bind to DNA as a heterodimer with PAX7. Interacts with DAXX. Belongs to the paired homeobox family. 7 isoforms of the human protein are produced by alternative splicing.

Protein type: DNA-binding; Transcription factor; Oncoprotein

Chromosomal Location of Human Ortholog: 2q35

Cellular Component: nucleus

Molecular Function: RNA polymerase II transcription factor activity, enhancer binding; protein binding; sequence-specific DNA binding; chromatin binding; transcription factor activity

Biological Process: transcription from RNA polymerase II promoter; cell proliferation; muscle development; organ morphogenesis; sensory perception of sound; apoptosis; heart development; positive regulation of transcription, DNA-dependent; positive regulation of cell proliferation; pigmentation during development; neural tube closure; neuron fate commitment; spinal cord association neuron differentiation; positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription from RNA polymerase II promoter; regulation of somitogenesis; neural crest cell migration

Disease: Waardenburg Syndrome, Type 3; Rhabdomyosarcoma 2; Craniofacial-deafness-hand Syndrome; Waardenburg Syndrome, Type 1

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