C1QTNF5, Polyclonal Antibody

LORD; CTRP5

For Research Use Only. Not for use in diagnostic procedures.

Polyclonal

Guinea pig

The antibody detects endogenous levels of total C1QTNF5 protein.

Antigen affinity purification.

Guinea pig IgG in pH7.3 PBS, 0.05% NaN3, 50% Glycerol.

0.6 mg/ml (lot specific)

Store at -20 degree C

Small volumes of anti-C1QTNF5 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

This gene encodes a member of the a member of the C1q/tumor necrosis factor superfamily. The encoded protein may be a component of basement membranes and may play a role in cell adhesion. This gene is contained entirely within the 3' UTR of the membrane frizzled-related protein gene on chromosome 11q23 and both genes are expressed from a bicistronic transcript. Mutations in this gene have been associated with late-onset retinal degeneration.

Total protein Ab

Western Blot (WB)

Western blotting: 1:200-1:1000

Gel: 10%+12%SDS-PAGE Lysate: 40ug A549 cell Primary antibody: 1/300 dilution Secondary antibody dilution: 1/8000 Exposure time: 5 seconds

25,298 Da

C1q and tumor necrosis factor related protein 5

complement C1q tumor necrosis factor-related protein 5

Complement C1q tumor necrosis factor-related protein 5

CTRP5  [Similar Products]

C1QT5_HUMAN

This gene encodes a member of a family of proteins that function as components of basement membranes and may play a role in cell adhesion. Mutations in this gene have been associated with late-onset retinal degeneration. The protein may be encoded by either a bicistronic transcript including sequence from the upstream membrane frizzled-related protein gene (MFRP), or by a monocistronic transcript expressed from an internal promoter. [provided by RefSeq, Jun 2013]

C1QTNF5: Defects in C1QTNF5 are a cause of late-onset retinal degeneration (LORD). LORD is an autosomal dominant disorder characterized by onset in the fifth to sixth decade with night blindness and punctate yellow-white deposits in the retinal fundus, progressing to severe central and peripheral degeneration, with choroidal neovascularization and chorioretinal atrophy.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 11q23.3

Cellular Component: collagen

Disease: Late-onset Retinal Degeneration

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