Product Name
MC4R, Blocking Peptide
Full Product Name
MC4R Peptide
Product Synonym Names
Melanocortin receptor 4; MC4-R; melanocortin 4 receptor
Product Gene Name
MC4R blocking peptide
[Similar Products]
MC4R peptide (MBS152190) is used for blocking the activity of MC4R antibody (MBS150230)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P32245
Concentration
200 ug/mL (lot specific)
Buffer
PBS pH 7.2 (10 mM NaH2PO4, 10 mM Na2HPO4, 130 mM NaCl) containing 0.1% bovine serum albumin and 0.02% sodium azide
Location
19 amino acids near the amino terminus of human MC4R.
Preparation and Storage
Store MC4R peptide at -20 degree C, stable for one year.
Other Notes
Small volumes of MC4R blocking peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for MC4R blocking peptide
Blocking (BL)
Application Notes for MC4R blocking peptide
MC4R peptide is used for blocking the activity of MC4R antibody.
Western Blot (WB) of MC4R blocking peptide
Western blot analysis of MC4R in rat brain tissue lysate with MC4R antibody at 1 μg/mL in (A) the absence and (B) the presence of blocking peptide.
NCBI/Uniprot data below describe general gene information for MC4R. It may not necessarily be applicable to this product.
NCBI Accession #
NP_005903
[Other Products]
NCBI GenBank Nucleotide #
NM_005912.2
[Other Products]
UniProt Primary Accession #
P32245
[Other Products]
UniProt Secondary Accession #
Q16317; Q3MIJ6; B2RAC3[Other Products]
UniProt Related Accession #
P32245[Other Products]
Molecular Weight
36,943 Da
NCBI Official Full Name
melanocortin receptor 4
NCBI Official Synonym Full Names
melanocortin 4 receptor
NCBI Official Symbol
MC4R [Similar Products]
NCBI Protein Information
melanocortin receptor 4; MC4-R
UniProt Protein Name
Melanocortin receptor 4
Protein Family
Melanocortin receptor
UniProt Gene Name
MC4R [Similar Products]
UniProt Synonym Gene Names
MC4-R [Similar Products]
UniProt Entry Name
MC4R_HUMAN
NCBI Summary for MC4R
The protein encoded by this gene is a membrane-bound receptor and member of the melanocortin receptor family. The encoded protein interacts with adrenocorticotropic and MSH hormones and is mediated by G proteins. This is an intronless gene. Defects in this gene are a cause of autosomal dominant obesity. [provided by RefSeq, Jan 2010]
UniProt Comments for MC4R
MC4R: receptor specific to the heptapeptide core common to adrenocorticotropic hormone and alpha-, beta-, and gamma-MSH. A G-protein coupled receptor that stimulates adenylate cyclase. Defects are a cause of autosomal dominant obesity
Protein type: Membrane protein, integral; Receptor, GPCR; GPCR, family 1; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 18q22
Cellular Component: plasma membrane; integral to membrane; nucleus
Molecular Function: neuropeptide binding; protein binding; melanocortin receptor activity; peptide hormone binding; melanocyte stimulating hormone receptor activity; ubiquitin protein ligase binding
Biological Process: G-protein signaling, coupled to cAMP nucleotide second messenger; diet induced thermogenesis; insulin secretion; positive regulation of cAMP biosynthetic process; energy reserve metabolic process; positive regulation of bone resorption; feeding behavior; response to insulin stimulus
Disease: Obesity
Research Articles on MC4R
1. We identified differences in the striatal response to food cues between two groups of obese individuals, those with and those without MC4R mutations.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
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