Full Product Name
Anti-SOX9 Rabbit pAb
Product Synonym Names
CMD1; Sox9; SRA1; SRXX2; SRXY10; SRY (sex determining region Y) box 9; Transcription factor SOX 9
Product Gene Name
anti-SOX9 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P48436
Species Reactivity
Human, Mouse, Rat
Specificity
SOX9 Antibody detects endogenous levels of SOX9
Purity/Purification
Affinity Chromatography
Form/Format
Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Immunogen
A synthesized peptide derived from human SOX9
Subcellular Location
Secreted
Preparation and Storage
Store at 4 degree C for short term.
Store at-20 degree C for long term.
Avoid freeze/thaw cycle.
Other Notes
Small volumes of anti-SOX9 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-SOX9 antibody
Regulates several important processes during embryonic development including chondrogenesis, during which it contributes to skeletal formation and digit specification (2, 3). Sox9 also coordinates with steroidogenic factor-1 to direct Sertoli cell-specific expression of anti-Mullerian hormone during embryogenesis, thereby contributing to male sex determination.
Applications Tested/Suitable for anti-SOX9 antibody
Western Blot (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunofluorescence (IF), Immunoprecipitation (IP), Flow Cytometry (FC/FACS)
Application Notes for anti-SOX9 antibody
WB: 1:1000-1:2000
IHC: 1:100-1:500
ICC/IF: 1:50-1:200
IP: 1:50
FC/FACS: 1:100
Western Blot (WB) of anti-SOX9 antibody
Western blot analysis of SOX9 expression in SW480 cell lysate.
Immunohistochemistry (IHC) of anti-SOX9 antibody
Immunohistochemical analysis of paraffin-embedded human colon, using SOX9 Antibody.
Immunofluorescence (IF) of anti-SOX9 antibody
Immunofluorescent analysis of SW480 cells, using SOX9 Antibody.
NCBI/Uniprot data below describe general gene information for SOX9. It may not necessarily be applicable to this product.
NCBI Accession #
NP_000337.1
[Other Products]
NCBI GenBank Nucleotide #
NM_000346.3
[Other Products]
UniProt Primary Accession #
P48436
[Other Products]
UniProt Secondary Accession #
Q53Y80[Other Products]
UniProt Related Accession #
P48436[Other Products]
NCBI Official Full Name
transcription factor SOX-9
NCBI Official Synonym Full Names
SRY-box 9
NCBI Official Symbol
SOX9 [Similar Products]
NCBI Official Synonym Symbols
CMD1; SRA1; CMPD1; SRXX2; SRXY10
[Similar Products]
NCBI Protein Information
transcription factor SOX-9
UniProt Protein Name
Transcription factor SOX-9
Protein Family
Transcription factor
UniProt Gene Name
SOX9 [Similar Products]
NCBI Summary for SOX9
The protein encoded by this gene recognizes the sequence CCTTGAG along with other members of the HMG-box class DNA-binding proteins. It acts during chondrocyte differentiation and, with steroidogenic factor 1, regulates transcription of the anti-Muellerian hormone (AMH) gene. Deficiencies lead to the skeletal malformation syndrome campomelic dysplasia, frequently with sex reversal. [provided by RefSeq, Jul 2008]
UniProt Comments for SOX9
Transcriptional regulator (PubMed:24038782). Binds to the COL2A1 promoter and activates COL2A1 expression, as part of a complex with ZNF219 (). Plays a role in chondrocyte differentiation (). Important for normal skeletal development (PubMed:24038782).
Research Articles on SOX9
1. Diagnostic tools such as whole-exome sequencing, targeted-gene sequencing and low-density CNV arrays, often miss CNVs within the SOX9 regulatory region. Yet, given the numerous reports, it is likely that CNVs in the SOX9 regulatory region may be a frequent genetic cause of 46,XX DSD.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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