Full Product Name
SOX9 Antibody
Product Gene Name
anti-SOX9 antibody
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Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P48436
Other Notes
Small volumes of anti-SOX9 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for SOX9. It may not necessarily be applicable to this product.
NCBI Accession #
NP_000337.1
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NCBI GenBank Nucleotide #
NM_000346.3
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UniProt Primary Accession #
P48436
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UniProt Secondary Accession #
Q53Y80[Other Products]
UniProt Related Accession #
P48436[Other Products]
Molecular Weight
56,137 Da
NCBI Official Full Name
transcription factor SOX-9
NCBI Official Synonym Full Names
SRY-box 9
NCBI Official Symbol
SOX9 [Similar Products]
NCBI Official Synonym Symbols
CMD1; SRA1; CMPD1; SRXX2; SRXY10
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NCBI Protein Information
transcription factor SOX-9
UniProt Protein Name
Transcription factor SOX-9
Protein Family
Transcription factor
UniProt Gene Name
SOX9 [Similar Products]
NCBI Summary for SOX9
The protein encoded by this gene recognizes the sequence CCTTGAG along with other members of the HMG-box class DNA-binding proteins. It acts during chondrocyte differentiation and, with steroidogenic factor 1, regulates transcription of the anti-Muellerian hormone (AMH) gene. Deficiencies lead to the skeletal malformation syndrome campomelic dysplasia, frequently with sex reversal. [provided by RefSeq, Jul 2008]
UniProt Comments for SOX9
Transcriptional regulator (PubMed:24038782). Binds to the COL2A1 promoter and activates COL2A1 expression, as part of a complex with ZNF219 (). Plays a role in chondrocyte differentiation (). Important for normal skeletal development (PubMed:24038782).
Research Articles on SOX9
1. Diagnostic tools such as whole-exome sequencing, targeted-gene sequencing and low-density CNV arrays, often miss CNVs within the SOX9 regulatory region. Yet, given the numerous reports, it is likely that CNVs in the SOX9 regulatory region may be a frequent genetic cause of 46,XX DSD.
Precautions
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Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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