slingshot homolog 1 (Drosophila), ELISA Kit

Human Protein phosphatase Slingshot homolog 1 (SSH1) ELISA kit; FLJ21928; FLJ38102; KIAA1298; SSH1L; slingshot 1; slingshot homolog 1 (Drosophila)

For Research Use Only. Not for use in diagnostic procedures.

Store all reagents at 2-8 degree C

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Small volumes of SSH1 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS9343136 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the slingshot homolog 1 (Drosophila) (SSH1) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing SSH1. The ELISA analytical biochemical technique of the MBS9343136 kit is based on SSH1 antibody-SSH1 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect SSH1 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, SSH1. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).

115,511 Da

slingshot protein phosphatase 1

protein phosphatase Slingshot homolog 1; hSSH-1L; SSH-like protein 1; slingshot homolog 1

Protein phosphatase Slingshot homolog 1

KIAA1298; SSH1L; SSH-1L; hSSH-1L  [Similar Products]

SSH1_HUMAN

The protein encoded by this gene belongs to the slingshot homolog (SSH) family of phosphatases, which regulate actin filament dynamics. The SSH proteins dephosphorylate and activate the actin binding/depolymerizing factor cofilin, which subsequently binds to actin filaments and stimulates their disassembly. Cofilin is inactivated by kinases such as LIM domain kinase-1 (LIMK1), which may also be dephosphorylated and inactivated by SSH proteins. The SSH family thus appears to play a role in actin dynamics by reactivating cofilin proteins. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011]

SSH1: a dual-specificity phosphatase of the Slingshot family involved in actin reorganization. Its calcineurin-dependent activation dephosphorylates cofilin. Plays a role in later stages of mitosis by dephosphorylating and activating cofilin.

Protein type: EC 3.1.3.16; Protein phosphatase, dual-specificity; EC 3.1.3.48

Chromosomal Location of Human Ortholog: 12q24.11

Cellular Component: nucleoplasm; cytoskeleton; lamellipodium; cytoplasm; plasma membrane; midbody; cleavage furrow

Molecular Function: protein binding; DNA binding; protein tyrosine/serine/threonine phosphatase activity; protein tyrosine phosphatase activity; actin binding; phosphoprotein phosphatase activity

Biological Process: regulation of cellular protein metabolic process; regulation of actin polymerization and/or depolymerization; cell morphogenesis; actin cytoskeleton organization and biogenesis; protein amino acid dephosphorylation; regulation of axonogenesis

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