Full Product Name
ANO6 Antibody, FITC conjugated
Product Synonym Names
Anoctamin-6; Small-conductance calcium-activated nonselective cation channel; SCAN channel; Transmembrane protein 16F; ANO6; TMEM16F
Product Gene Name
anti-ANO6 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
OMIM
AC009248 Genomic DNA
3D Structure
ModBase 3D Structure for Q4KMQ2
Purity/Purification
>95%, Protein G purified
Immunogen
Recombinant Human Anoctamin-6 protein (12-100AA)
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Preparation and Storage
Upon receipt, store at -20 degree C or -80 degree C. Avoid repeated freeze.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of anti-ANO6 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-ANO6 antibody
Small-conductance calcium-activated nonselective cation (SCAN) channel which acts as a regulator of phospholipid scrambling in platelets and osteoblasts. Phospholipid scrambling results in surface exposure of phosphatidylserine which in platelets is essential to trigger the clotting system whereas in osteoblasts is essential for the deposition of hydroxyapatite during bone mineralization. Has calcium-dependent phospholipid scramblase activity; scrambles phosphatidylserine, phosphatidylcholine and galactosylceramide (By similarity). Can generate outwardly rectifying chloride channel currents in airway epithelial cells and Jurkat T lymphocytes.
Product Categories/Family for anti-ANO6 antibody
Others
Applications Tested/Suitable for anti-ANO6 antibody
ELISA (EIA)
NCBI/Uniprot data below describe general gene information for ANO6. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001020527.2
[Other Products]
NCBI GenBank Nucleotide #
NM_001025356.2
[Other Products]
UniProt Primary Accession #
Q4KMQ2
[Other Products]
UniProt Secondary Accession #
Q8N3Q2; A6NNM6; B9EGG0; E7ENK4; E9PB30; E9PCT2[Other Products]
UniProt Related Accession #
Q4KMQ2[Other Products]
Molecular Weight
108,102 Da
NCBI Official Full Name
anoctamin-6 isoform a
NCBI Official Synonym Full Names
anoctamin 6
NCBI Official Symbol
ANO6 [Similar Products]
NCBI Official Synonym Symbols
SCTS; BDPLT7; TMEM16F
[Similar Products]
NCBI Protein Information
anoctamin-6
UniProt Protein Name
Anoctamin-6
UniProt Synonym Protein Names
Small-conductance calcium-activated nonselective cation channel; SCAN channel; Transmembrane protein 16F
UniProt Gene Name
ANO6 [Similar Products]
UniProt Synonym Gene Names
TMEM16F; SCAN channel [Similar Products]
NCBI Summary for ANO6
This gene encodes a multi-pass transmembrane protein that belongs to the anoctamin family. This protein is an essential component for the calcium-dependent exposure of phosphatidylserine on the cell surface. The scrambling of phospholipid occurs in various
biological systems, such as when blood platelets are activated, they expose phosphatidylserine to trigger the clotting system. Mutations in this gene are associated with Scott syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2011]
UniProt Comments for ANO6
Small-conductance calcium-activated nonselective cation (SCAN) channel which acts as a regulator of phospholipid scrambling in platelets and osteoblasts. Phospholipid scrambling results in surface exposure of phosphatidylserine which in platelets is essential to trigger the clotting system whereas in osteoblasts is essential for the deposition of hydroxyapatite during bone mineralization. Has calcium-dependent phospholipid scramblase activity; scrambles phosphatidylserine, phosphatidylcholine and galactosylceramide (). Can generate outwardly rectifying chloride channel currents in airway epithelial cells and Jurkat T lymphocytes.
Research Articles on ANO6
1. ICl,Swell, and cell volume are regulated by Ano6. The findings suggest a novel clinically-relevant approach for altering cell volume, and thereby outflow resistance, by targeting Ano6.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
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