Full Product Name
MUTYH Antibody
Product Synonym Names
MGC4416; MYH
Product Gene Name
anti-MUTYH antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q9UIF7
Species Reactivity
Human, Mouse, Rat
Purity/Purification
Affinity purification
Immunogen
Recombinant protein of human MUTYH
Storage Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Preparation and Storage
Store at-20 degree C or-80 degree C. Avoid freeze/thaw cycles.
Other Notes
Small volumes of anti-MUTYH antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-MUTYH antibody
Base excision repair (BER) proteins catalyze the removal of incorrect or damaged bases, including oxidized bases, from DNA. N-glycosylases specific to a given lesion remove the incorrect base as the first step in BER. MYH is the mammalian ortholog of E. coli MutY, a DNA glycosylase that catalyzes the removal of 8-oxoG:A mismatches (1). Several MYH isoforms have been detected in human cells localizing to either the nucleus or the mitochondria (2). MYH interacts with DNA repair proteins and localizes to DNA damage foci after oxidative damage (3). Research studies have shown that mutations in the corresponding MYH gene are associated with human gastric (4) and colorectal (5-7) cancers.
Product Categories/Family for anti-MUTYH antibody
Autophagy antibody; Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells
Applications Tested/Suitable for anti-MUTYH antibody
Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-MUTYH antibody
WB: 1:500-1:2000
IHC: 1:50-1:200
Testing Data of anti-MUTYH antibody
Western blot analysis of extracts of variouscell lines, using MUTYH antibody.
NCBI/Uniprot data below describe general gene information for MUTYH. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001041636.1
[Other Products]
NCBI GenBank Nucleotide #
NM_001048171.1
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UniProt Primary Accession #
Q9UIF7
[Other Products]
UniProt Secondary Accession #
Q15830; Q9UBP2; Q9UBS7; Q9UIF4; Q9UIF5; Q9UIF6; D3DPZ4[Other Products]
UniProt Related Accession #
Q9UIF7[Other Products]
NCBI Official Full Name
adenine DNA glycosylase isoform 2
NCBI Official Synonym Full Names
mutY DNA glycosylase
NCBI Official Symbol
MUTYH [Similar Products]
NCBI Official Synonym Symbols
MYH
[Similar Products]
NCBI Protein Information
adenine DNA glycosylase
UniProt Protein Name
Adenine DNA glycosylase
UniProt Synonym Protein Names
MutY homolog; hMYH
UniProt Gene Name
MUTYH [Similar Products]
UniProt Synonym Gene Names
MYH; hMYH [Similar Products]
NCBI Summary for MUTYH
This gene encodes a DNA glycosylase involved in oxidative DNA damage repair. The enzyme excises adenine bases from the DNA backbone at sites where adenine is inappropriately paired with guanine, cytosine, or 8-oxo-7,8-dihydroguanine, a major oxidatively damaged DNA lesion. The protein is localized to the nucleus and mitochondria. This gene product is thought to play a role in signaling apoptosis by the introduction of single-strand breaks following oxidative damage. Mutations in this gene result in heritable predisposition to colorectal cancer, termed MUTYH-associated polyposis (MAP). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2017]
UniProt Comments for MUTYH
Involved in oxidative DNA damage repair. Initiates repair of A*oxoG to C*G by removing the inappropriately paired adenine base from the DNA backbone. Possesses both adenine and 2-OH-A DNA glycosylase activities.
Product References and Citations for anti-MUTYH antibody
1. Slupska, M.M. et al. (1996) J Bacteriol 178, 3885-92. 2. Ohtsubo, T. et al. (2000) Nucleic Acids Res 28, 1355-64. 3. Shi, G. et al. (2006) Biochem J 400, 53-62. 4. Kobayashi, K. et al. (2008) Anticancer Res 28, 215-21. 5. Bai, H. et al. (2007) Cancer Lett 250, 74-81. 6. Pope, M.A. et al. (2005) DNA Repair (Amst) 4, 315-25. 7. Wooden, S.H. et al. (2004) Cancer Lett 205, 89-95.
Research Articles on MUTYH
1. Our results suggest that p.(Gly396Asp) in MUTYH, and potentially other mutations in additional members of the same DNA excision-repair pathway (such as the OGG1 gene) might be involved in driving the tumorigenesis leading to familial and sporadic small intestinal neuroendocrine tumors .
Precautions
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Disclaimer
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