Full Product Name
MUTYH Antibody
Product Gene Name
anti-MUTYH antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q9UIF7
Other Notes
Small volumes of anti-MUTYH antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
NCBI/Uniprot data below describe general gene information for MUTYH. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001041636.1
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NCBI GenBank Nucleotide #
NM_001048171.1
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UniProt Primary Accession #
Q9UIF7
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UniProt Secondary Accession #
Q15830; Q9UBP2; Q9UBS7; Q9UIF4; Q9UIF5; Q9UIF6; D3DPZ4[Other Products]
UniProt Related Accession #
Q9UIF7[Other Products]
Molecular Weight
57,446 Da
NCBI Official Full Name
adenine DNA glycosylase isoform 2
NCBI Official Synonym Full Names
mutY DNA glycosylase
NCBI Official Symbol
MUTYH [Similar Products]
NCBI Official Synonym Symbols
MYH
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NCBI Protein Information
adenine DNA glycosylase
UniProt Protein Name
Adenine DNA glycosylase
UniProt Synonym Protein Names
MutY homolog; hMYH
UniProt Gene Name
MUTYH [Similar Products]
UniProt Synonym Gene Names
MYH; hMYH [Similar Products]
NCBI Summary for MUTYH
This gene encodes a DNA glycosylase involved in oxidative DNA damage repair. The enzyme excises adenine bases from the DNA backbone at sites where adenine is inappropriately paired with guanine, cytosine, or 8-oxo-7,8-dihydroguanine, a major oxidatively damaged DNA lesion. The protein is localized to the nucleus and mitochondria. This gene product is thought to play a role in signaling apoptosis by the introduction of single-strand breaks following oxidative damage. Mutations in this gene result in heritable predisposition to colorectal cancer, termed MUTYH-associated polyposis (MAP). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2017]
UniProt Comments for MUTYH
Involved in oxidative DNA damage repair. Initiates repair of A*oxoG to C*G by removing the inappropriately paired adenine base from the DNA backbone. Possesses both adenine and 2-OH-A DNA glycosylase activities.
Research Articles on MUTYH
1. Our results suggest that p.(Gly396Asp) in MUTYH, and potentially other mutations in additional members of the same DNA excision-repair pathway (such as the OGG1 gene) might be involved in driving the tumorigenesis leading to familial and sporadic small intestinal neuroendocrine tumors .
Precautions
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Disclaimer
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