Full Product Name
Rabbit MUTYH Antibody
Product Gene Name
anti-MUTYH antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Chromosome Location
Chromosome: 1; NC_000001.10 (45794914..45806142, complement). Location: 1p34.1
3D Structure
ModBase 3D Structure for Q9UIF7
Species Reactivity
Human, mouse, rat
Form/Format
Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol
Concentration
1 mg/ml (lot specific)
Other Notes
Small volumes of anti-MUTYH antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-MUTYH antibody
ELISA (EIA), Immunofluorescence (IF), Western Blot (WB)
NCBI/Uniprot data below describe general gene information for MUTYH. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001041636.1
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NCBI GenBank Nucleotide #
NM_001048171.1
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UniProt Primary Accession #
Q9UIF7
[Other Products]
UniProt Secondary Accession #
Q15830; Q9UBP2; Q9UBS7; Q9UIF4; Q9UIF5; Q9UIF6; D3DPZ4[Other Products]
UniProt Related Accession #
Q9UIF7[Other Products]
Molecular Weight
60,069 Da
NCBI Official Full Name
A/G-specific adenine DNA glycosylase isoform 2
NCBI Official Synonym Full Names
mutY homolog (E. coli)
NCBI Official Symbol
MUTYH [Similar Products]
NCBI Official Synonym Symbols
MYH; CYP2C
[Similar Products]
NCBI Protein Information
A/G-specific adenine DNA glycosylase
UniProt Protein Name
A/G-specific adenine DNA glycosylase
UniProt Synonym Protein Names
MutY homolog
UniProt Gene Name
MUTYH [Similar Products]
UniProt Synonym Gene Names
MYH; hMYH [Similar Products]
UniProt Entry Name
MUTYH_HUMAN
NCBI Summary for MUTYH
This gene encodes a DNA glycosylase involved in oxidative DNA damage repair. The enzyme excises adenine bases from the DNA backbone at sites where adenine is inappropriately paired with guanine, cytosine, or 8-oxo-7,8-dihydroguanine, a major oxidatively damaged DNA lesion. The protein is localized to the nucleus and mitochondria. Mutations in this gene result in heritable predisposition to colon and stomach cancer. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
UniProt Comments for MUTYH
MUTYH: Involved in oxidative DNA damage repair. Initiates repair of A*oxoG to C*G by removing the inappropriately paired adenine base from the DNA backbone. Possesses both adenine and 2- OH-A DNA glycosylase activities. Belongs to the Nth/MutY family. 6 isoforms of the human protein are produced by alternative splicing.
Protein type: DNA repair, damage; EC 3.2.2.-; Tumor suppressor; Hydrolase; Mitochondrial
Chromosomal Location of Human Ortholog: 1p34.1
Cellular Component: nucleoplasm; mitochondrion; nucleus
Molecular Function: protein binding; 4 iron, 4 sulfur cluster binding; metal ion binding; hydrolase activity, acting on glycosyl bonds; MutLalpha complex binding; MutSbeta complex binding; MutLbeta complex binding; MutSalpha complex binding
Biological Process: mismatch repair; depurination; base-excision repair, AP site formation; base-excision repair; DNA repair
Disease: Gastric Cancer; Pilomatrixoma; Familial Adenomatous Polyposis, 2
Research Articles on MUTYH
1. C alters splicing causing the synthesis of a non functional protein.">The notion that MUTYH c.933+3A>C alters splicing causing the synthesis of a non functional protein.
Precautions
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Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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