Product Name
GCAP1 (GUCA1A), Blocking Peptide
Full Product Name
GCAP1 Antibody (C-term) Blocking Peptide
Product Synonym Names
Guanylyl cyclase-activating protein 1; GCAP 1; Guanylate cyclase activator 1A; GUCA1A; C6orf131; GCAP; GCAP1; GUCA1
Product Gene Name
GUCA1A blocking peptide
[Similar Products]
Product Synonym Gene Name
C6orf131; GCAP; GCAP1; GUCA1[Similar Products]
Antibody/Peptide Pairs
GCAP1 peptide (MBS9221344) is used for blocking the activity of GCAP1 antibody (MBS9201773)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P43080
Specificity
The synthetic peptide sequence used to generate the antibody was selected from the C-term region of human GCAP1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Form/Format
The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.
Cellular Location
Membrane; Lipid-anchor.
Tissue Location
Retina; cone outer and inner segments, in particular, in disk membrane regions, and to a lesser extent rod inner and outer segments
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.
Other Notes
Small volumes of GUCA1A blocking peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
GUCA1A blocking peptide
Stimulates guanylyl cyclase 1 (GC1) when free calcium ions concentration is low and inhibits GC1 when free calcium ions concentration is elevated. This Ca(2+)-sensitive regulation of GC is a key event in recovery of the dark state of rod photoreceptors following light exposure.
NCBI/Uniprot data below describe general gene information for GUCA1A. It may not necessarily be applicable to this product.
NCBI Accession #
P43080.3
[Other Products]
UniProt Primary Accession #
P43080
[Other Products]
UniProt Secondary Accession #
Q7Z6T1; Q9NU14; B3KWT4[Other Products]
UniProt Related Accession #
P43080[Other Products]
Molecular Weight
22,920 Da
NCBI Official Full Name
Guanylyl cyclase-activating protein 1
NCBI Official Synonym Full Names
guanylate cyclase activator 1A
NCBI Official Symbol
GUCA1A [Similar Products]
NCBI Official Synonym Symbols
COD3; GCAP; GUCA; GCAP1; GUCA1; CORD14; C6orf131
[Similar Products]
NCBI Protein Information
guanylyl cyclase-activating protein 1
UniProt Protein Name
Guanylyl cyclase-activating protein 1
UniProt Synonym Protein Names
Guanylate cyclase activator 1A
Protein Family
Guanylyl cyclase-activating protein
UniProt Gene Name
GUCA1A [Similar Products]
UniProt Synonym Gene Names
C6orf131; GCAP; GCAP1; GUCA1; GCAP 1 [Similar Products]
UniProt Entry Name
GUC1A_HUMAN
NCBI Summary for GUCA1A
This gene encodes an enzyme that plays a role in the recovery of retinal photoreceptors from photobleaching. This enzyme promotes the activity of retinal guanylyl cyclase-1 (GC1) at low calcium concentrations and inhibits GC1 at high calcium concentrations. Mutations in this gene can cause cone dystrophy 3 and code-rod dystrophy 14. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]
UniProt Comments for GUCA1A
GUCA1A: Stimulates guanylyl cyclase 1 (GC1) when free calcium ions concentration is low and inhibits GC1 when free calcium ions concentration is elevated. This Ca(2+)-sensitive regulation of GC is a key event in recovery of the dark state of rod photoreceptors following light exposure. Defects in GUCA1A are the cause of cone dystrophy type 3 (COD3). COD3 is an autosomal dominant cone dystrophy. Cone dystrophies are retinal dystrophies characterized by progressive degeneration of the cone photoreceptors with preservation of rod function, as indicated by electroretinogram. However, some rod involvement may be present in some cone dystrophies, particularly at late stage. Affected individuals suffer from photophobia, loss of visual acuity, color vision and central visual field. Another sign is the absence of macular lesions for many years. Cone dystrophies are distinguished from the cone-rod dystrophies, in which some loss of peripheral vision also occurs.
Chromosomal Location of Human Ortholog: 6p21.1
Cellular Component: plasma membrane
Molecular Function: calcium ion binding; calcium sensitive guanylate cyclase activator activity; guanylate cyclase regulator activity
Biological Process: positive regulation of guanylate cyclase activity; regulation of rhodopsin mediated signaling
Disease: Cone Dystrophy 3
Research Articles on GUCA1A
1. Dimerization domain of RETGC1 is an essential part of GCAP1 and GCAP2 binding interface.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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