Extracellular calcium-sensing receptor, Recombinant Protein

Parathyroid cell calcium-sensing receptor 1; PCaR1

For Research Use Only. Not for use in diagnostic procedures.

Yeast

Greater than 90% as determined by SDS-PAGE.

20mM Tris-HCl based buffer, pH8.0

Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C. Repeated freezing and thawing is not recommended. Store working aliquots at 4 degree C for up to one week.

Small volumes of CASR recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Senses changes in the extracellular concentration of calcium ions. The activity of this receptor is mediated by a G-protein that activates a phosphatidylinositol-calcium second messenger syst.

68.4kD

calcium sensing receptor

extracellular calcium-sensing receptor

Extracellular calcium-sensing receptor

PCaR1  [Similar Products]

The protein encoded by this gene is a G protein-coupled receptor that is expressed in the parathyroid hormone (PTH)-producing chief cells of the parathyroid gland, and the cells lining the kidney tubule. It senses small changes in circulating calcium concentration and couples this information to intracellular signaling pathways that modify PTH secretion or renal cation handling, thus this protein plays an essential role in maintaining mineral ion homeostasis. Mutations in this gene cause familial hypocalciuric hypercalcemia, familial, isolated hypoparathyroidism, and neonatal severe primary hyperparathyroidism. [provided by RefSeq, Jul 2008]

CaR: a G-protein coupled receptor that activates a phosphatidylinositol-calcium second messenger system. Functions as a calcium sensor for parathyroid and kidney to determine the extracellular calcium concentration and thus helps to maintain a stable calcium concentration. Two alternatively-spliced isoforms have been described.

Protein type: GPCR, family 3; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis; Receptor, GPCR

Chromosomal Location of Human Ortholog: 3q13.33-q21.1

Cellular Component: integral to plasma membrane; plasma membrane

Molecular Function: amino acid binding; calcium ion binding; G-protein coupled receptor activity; phosphoinositide phospholipase C activity; protein binding; protein homodimerization activity

Biological Process: anatomical structure morphogenesis; cellular calcium ion homeostasis; chemosensory behavior; detection of calcium ion; G-protein coupled receptor protein signaling pathway; ossification

Disease: Epilepsy, Idiopathic Generalized, Susceptibility To, 8; Hyperparathyroidism, Neonatal Severe; Hypocalcemia, Autosomal Dominant 1; Hypocalciuric Hypercalcemia, Familial, Type I

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