Full Product Name
DGKQ Antibody
Product Synonym Names
DAGK; DAGK4; DAGK7
Product Gene Name
anti-DGKQ antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Species Reactivity
Human, Mouse, Rat
Purity/Purification
Antigen affinity purification
Immunogen
Fusion protein of DGKQ
Calculated Molecular Weight: 942aa; 101kd
Observed Molecular Weight: 110kd
Buffer
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Santa Cruz Alternative
Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-46577 / sc-66861
Preparation and Storage
Store at -20 degree C. Avoid freeze / thaw cycles
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Other Notes
Small volumes of anti-DGKQ antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-DGKQ antibody
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-DGKQ antibody
WB: 1:200-1:2000
IHC: 1:20-1:200
Testing Data of anti-DGKQ antibody
NCBI/Uniprot data below describe general gene information for DGKQ. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001338.2
[Other Products]
NCBI GenBank Nucleotide #
NM_001347.3
[Other Products]
UniProt Secondary Accession #
Q6P3W4[Other Products]
UniProt Related Accession #
P52824[Other Products]
Molecular Weight
101,155 Da
NCBI Official Full Name
diacylglycerol kinase theta
NCBI Official Synonym Full Names
diacylglycerol kinase, theta 110kDa
NCBI Official Symbol
DGKQ [Similar Products]
NCBI Official Synonym Symbols
DAGK; DAGK4; DAGK7
[Similar Products]
NCBI Protein Information
diacylglycerol kinase theta; DAG kinase theta; DGK-theta; diglyceride kinase theta
UniProt Protein Name
Diacylglycerol kinase theta
UniProt Synonym Protein Names
Diglyceride kinase theta; DGK-theta
Protein Family
Diacylglycerol kinase
UniProt Gene Name
DGKQ [Similar Products]
UniProt Synonym Gene Names
DAGK4; DAG kinase theta; DGK-theta [Similar Products]
UniProt Entry Name
DGKQ_HUMAN
NCBI Summary for DGKQ
The protein encoded by this gene contains three cysteine-rich domains, a proline-rich region, and a pleckstrin homology domain with an overlapping Ras-associating domain. It is localized in the speckle domains of the nucleus, and mediates the regeneration of phosphatidylinositol (PI) from diacylglycerol in the PI-cycle during cell signal transduction. [provided by RefSeq, Jul 2008]
UniProt Comments for DGKQ
DGKQ: Phosphorylates diacylglycerol (DAG) to generate phosphatidic acid (PA). May regulate the activity of protein kinase C by controlling the balance between these two signaling lipids. Activated in the nucleus in response to alpha-thrombin and nerve growth factor. May be involved in cAMP- induced activation of NR5A1 and subsequent steroidogenic gene transcription by delivering PA as ligand for NR5A1. Acts synergistically with NR5A1 on CYP17 transcriptional activity. Belongs to the eukaryotic diacylglycerol kinase family.
Protein type: Kinase, lipid; Lipid Metabolism - glycerophospholipid; Lipid Metabolism - glycerolipid; EC 2.7.1.107; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 4p16.3
Cellular Component: cytoskeleton; cytoplasm; plasma membrane; nuclear speck; cytosol; nucleus
Molecular Function: protein binding; phospholipase binding; transcription activator binding; metal ion binding; diacylglycerol kinase activity; kinase binding; ATP binding; NAD+ kinase activity
Biological Process: regulation of transcription from RNA polymerase II promoter; platelet activation; G-protein coupled receptor protein signaling pathway; cAMP-mediated signaling; protein kinase C activation; blood coagulation; phosphorylation; response to ATP
Research Articles on DGKQ
1. these data demonstrate that DGKtheta; plays an important role in steroid hormone production in human adrenocortical cells
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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