Anoctamin 6 (ANO6), Antibody

TMEM16F; SCAN channel; Transmembrane Protein 16F; Small-conductance calcium-activated nonselective cation channel

For Research Use Only. Not for use in diagnostic procedures.

Rabbit

Antigen-specific Affinity Chromatography.

Supplied as solution form in PBS, pH7.4, 50% glycerol 0.05% Proclin-300.

0.67 mg/ml (lot specific)

Storage: Avoid repeated freeze/thaw cycles.
Store at 4°C for frequent use.
Aliquot and store at -20°C for 24 months.

Stability Test: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.

Manufactured in an ISO 9001:2008 and ISO 13485:2003 Certified Laboratory.

Manufactured in a lab with traceable raw materials. Bulk orders can typically be prepared to the customer’s specifications, please inquire.

Small volumes of anti-ANO6 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Western Blot (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunofluorescence (IF)

Western blotting: 0.5-2ug/mL
Immunohistochemistry: 5-20ug/mL
Immunocytochemistry: 5-20ug/mL
Optimal working dilutions must be determined by end user.

anoctamin 6

anoctamin-6

Anoctamin-6

TMEM16F; SCAN channel  [Similar Products]

This gene encodes a multi-pass transmembrane protein that belongs to the anoctamin family. This protein is an essential component for the calcium-dependent exposure of phosphatidylserine on the cell surface. The scrambling of phospholipid occurs in various biological systems, such as when blood platelets are activated, they expose phosphatidylserine to trigger the clotting system. Mutations in this gene are associated with Scott syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2011]

ANO6: May act as a calcium-activated chloride channel. It is essential for calcium-dependent exposure of phosphatidylserine on the surface of activated platelets, a process necessary to trigger the clotting system. Defects in ANO6 are the cause of Scott syndrome (SCTS). A mild bleeding disorder due to impaired surface exposure of procoagulant phosphatidylserine (PS) on platelets and other blood cells, following activation with Ca(2+)-elevating agents. Belongs to the anoctamin family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ion channel

Chromosomal Location of Human Ortholog: 12q12

Cellular Component: cell surface; cytosol; intracellular; membrane; plasma membrane

Molecular Function: calcium activated cation channel activity; intracellular calcium activated chloride channel activity; phospholipid scramblase activity; protein binding; protein homodimerization activity; voltage-gated chloride channel activity; voltage-gated ion channel activity

Biological Process: activation of blood coagulation via clotting cascade; bleb formation; blood coagulation; cation transport; chloride transport; dendritic cell chemotaxis; lipid transport; negative regulation of cell volume; neutrophil degranulation; phospholipid scrambling; pore complex assembly; positive regulation of apoptosis; positive regulation of bone mineralization; positive regulation of phagocytosis, engulfment

Disease: Scott Syndrome

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