Product Name
CD240 (CD240DCE), Monoclonal Antibody
Full Product Name
MOUSE ANTI HUMAN CD240DCE
Product Gene Name
anti-CD240DCE antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P18577
Specificity
This item recognises human erythrocytes of normal Rh types but does not recognise Rhnull erythrocytes. This item reacts with 31kD and 35-52kD proteins which were designated CD240DCE at the 7th leucocyte typing workshop.
Form/Format
Purified
Purified IgG - liquid
Concentration
IgG concentration 1.0mg/ml (lot specific)
Perservative Stabilisers
0.09% Sodium Azide
Immunogen
Human erythrocytes
Buffer Solution
Preparation and Storage
Store at 4 degree C or at -20 degree C if preferred. This product should be stored undiluted. Storage in frost free freezers is not recommended. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life: 18 months from date of despatch.
Other Notes
Small volumes of anti-CD240DCE antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-CD240DCE antibody
MBS212434 recognises human erythrocytes of normal Rh types but does not recognise Rhnull erythrocytes. MBS212434 reacts with 31kD and 35-52kD proteins which were designated CD240DCE at the 7th leucocyte typing workshop.
Applications Tested/Suitable for anti-CD240DCE antibody
Flow cytometry (FC/FACS), Immunoprecipitation (IP)
Application Notes for anti-CD240DCE antibody
Flow Cytometry: Use 10ul of the suggested working dilution to label 106 cells in 100ul.
NCBI/Uniprot data below describe general gene information for CD240DCE. It may not necessarily be applicable to this product.
NCBI Accession #
NP_065231.3
[Other Products]
NCBI GenBank Nucleotide #
NM_020485.4
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UniProt Primary Accession #
P18577
[Other Products]
UniProt Secondary Accession #
A7DW68; B7UDF3; B7UDF4; B7UDF5; B7UDF6; B7UDF7; B7UDF8; B7UDF9; B7UDG0; B7UDG1; B7UDG2[Other Products]
UniProt Related Accession #
P18577[Other Products]
Molecular Weight
26,852 Da
NCBI Official Full Name
blood group Rh(CE) polypeptide isoform 1
NCBI Official Synonym Full Names
Rh blood group, CcEe antigens
NCBI Official Symbol
RHCE [Similar Products]
NCBI Official Synonym Symbols
RH; RHC; RHE; Rh4; RHPI; RhVI; RH30A; RHIXB; RhVIII; CD240CE; RhIVb(J)
[Similar Products]
NCBI Protein Information
blood group Rh(CE) polypeptide; blood group Rh(CE) polypeptide; RHCE blood group variant Crawford antigen Rh43; Rh blood group C antigen; Rh blood group antigen Evans; Rh polypeptide I; Rhesus blood group CE protein; Rhesus blood group E antigen; Rhesus blood group Rhce antigen; Rhesus system C and E polypeptides; blood group RhCcEe antigen; rh polypeptide 1; rhesus C/E antigens; rhesus blood group antigen, RhC antigen; rhesus blood group little e antigen; silenced Rh blood group CcEe antigen; truncated RHCE
UniProt Protein Name
Blood group Rh(CE) polypeptide
UniProt Synonym Protein Names
Rh polypeptide 1; RhPI; Rh30A; RhIXB; Rhesus C/E antigens; CD_antigen: CD240CE
UniProt Gene Name
RHCE [Similar Products]
UniProt Synonym Gene Names
RHC; RHE; RhPI [Similar Products]
UniProt Entry Name
RHCE_HUMAN
NCBI Summary for CD240DCE
The Rh blood group system is the second most clinically significant of the blood groups, second only to ABO. It is also the most polymorphic of the blood groups, with variations due to deletions, gene conversions, and missense mutations. The Rh blood group includes this gene which encodes both the RhC and RhE antigens on a single polypeptide and a second gene which encodes the RhD protein. The classification of Rh-positive and Rh-negative individuals is determined by the presence or absence of the highly immunogenic RhD protein on the surface of erythrocytes. A mutation in this gene results in amorph-type Rh-null disease. Alternative splicing of this gene results in four transcript variants encoding four different isoforms. [provided by RefSeq, Jul 2008]
UniProt Comments for CD240DCE
RHCE: May be part of an oligomeric complex which is likely to have a transport or channel function in the erythrocyte membrane. Belongs to the ammonium transporter (TC 2.A.49) family. Rh subfamily. 14 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, multi-pass; Membrane protein, integral
Chromosomal Location of Human Ortholog: 1p36.11
Cellular Component: integral to plasma membrane
Molecular Function: ammonium transmembrane transporter activity
Disease: Blood Group--rhesus System E Polypeptide
Research Articles on CD240DCE
1. RHD*weak partial 4.0 is associated with an altered RHCE*ce(48C, 105T, 733G, 744C, 1025T) allele in the Tunisian population.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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