Full Product Name
GTF2I Antibody
Product Synonym Names
BAP-135; BAP135; BTKAP1; DIWS; FLJ38776; FLJ56355; IB291; SPIN; TFII-I; WBS; WBSCR6
Product Gene Name
anti-GTF2I antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Species Reactivity
Human, Mouse, Rat
Purity/Purification
Antigen affinity purification
Immunogen
Fusion protein of GTF2I
Calculated Molecular Weight: 112kd
Observed Molecular Weight: 135kd
Buffer
PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
Santa Cruz Alternative
Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-9943 / sc-9944 / sc-28716
Preparation and Storage
Store at -20 degree C. Avoid freeze / thaw cycles
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Other Notes
Small volumes of anti-GTF2I antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-GTF2I antibody
ELISA (EIA), Western Blot (WB), Immunofluorescence (IF)
Application Notes for anti-GTF2I antibody
WB: 1:200-1:2000
IF: 1:20-1:100
Testing Data of anti-GTF2I antibody
NCBI/Uniprot data below describe general gene information for GTF2I. It may not necessarily be applicable to this product.
NCBI Accession #
NP_127492.1
[Other Products]
NCBI GenBank Nucleotide #
NM_032999.3
[Other Products]
UniProt Secondary Accession #
O14743; O15359; O43546; O43588; O43589; Q75M85; Q75M86; Q75M87; Q75M88; Q86U51; Q9BSZ4[Other Products]
UniProt Related Accession #
P78347[Other Products]
Molecular Weight
30,409 Da
NCBI Official Full Name
general transcription factor II-I isoform 1
NCBI Official Synonym Full Names
general transcription factor IIi
NCBI Official Symbol
GTF2I [Similar Products]
NCBI Official Synonym Symbols
WBS; DIWS; SPIN; IB291; BAP135; BTKAP1; TFII-I; WBSCR6; GTFII-I
[Similar Products]
NCBI Protein Information
general transcription factor II-I; BTK-associated protein, 135kD; Bruton tyrosine kinase-associated protein 135; SRF-Phox1-interacting protein; Williams-Beuren syndrome chromosome region 6
UniProt Protein Name
General transcription factor II-I
UniProt Synonym Protein Names
Bruton tyrosine kinase-associated protein 135; BAP-135; BTK-associated protein 135; SRF-Phox1-interacting protein; SPIN; Williams-Beuren syndrome chromosomal region 6 protein
Protein Family
General transcription factor
UniProt Gene Name
GTF2I [Similar Products]
UniProt Synonym Gene Names
BAP135; WBSCR6; GTFII-I; TFII-I; BAP-135; BTK-associated protein 135; SPIN [Similar Products]
UniProt Entry Name
GTF2I_HUMAN
NCBI Summary for GTF2I
This gene encodes a phosphoprotein containing six characteristic repeat motifs. The encoded protein binds to the initiator element (Inr) and E-box element in promoters and functions as a regulator of transcription. This locus, along with several other neighboring genes, is deleted in Williams-Beuren syndrome. There are many closely related genes and pseudogenes for this gene on chromosome 7. This gene also has pseudogenes on chromosomes 9, 13, and 21. Alternatively spliced transcript variants encoding multiple isoforms have been observed. [provided by RefSeq, Jul 2013]
UniProt Comments for GTF2I
GTF2I: a multifunctional phosphoprotein with roles in transcription and signal transduction. Interacts with the basal transcription machinery by coordinating the formation of a multiprotein complex at the C-FOS promoter, and linking specific signal responsive activator complexes. Promotes the formation of stable high-order complexes of SRF and Phox1 and interacts cooperatively with Phox1 to promote serum-inducible transcription of a reporter gene driven by the C- FOS serum response element (SRE). Acts as a coregulator for USF1 by binding independently two promoter elements, a pyrimidine-rich initiator (Inr) and an upstream E-box. Its gene is known to contain at least 34 exons. Four splice variant isoforms have been described.
Protein type: DNA-binding; Transcription, coactivator/corepressor
Chromosomal Location of Human Ortholog: 7q11.23
Cellular Component: nucleoplasm; cell projection; membrane; cell soma; cytoplasm; nucleus
Molecular Function: protein binding; DNA binding; mitogen-activated protein kinase binding; transcription factor activity
Biological Process: transcription from RNA polymerase II promoter; transcription initiation from RNA polymerase II promoter; negative regulation of angiogenesis; regulation of transcription, DNA-dependent; transition between slow and fast fiber; reduction of cytosolic calcium ion concentration; signal transduction
Disease: Williams-beuren Syndrome
Research Articles on GTF2I
1. GTF2I mutation correlated with better survival.
Precautions
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Disclaimer
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