Full Product Name
FOXD3 (Forkhead Box D3, HFH2, HNF-3 Forkhead Transcription Factor Genesis)
Product Synonym Names
Anti -FOXD3 (Forkhead Box D3, HFH2, HNF-3 Forkhead Transcription Factor Genesis)
Product Gene Name
anti-FOXD3 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Chromosome Location
Chromosome: 1; NC_000001.10 (63788730..63790797). Location: 1p31.3
3D Structure
ModBase 3D Structure for Q9UJU5
Specificity
Recognizes human FOXD3.
Purity/Purification
Affinity Purified
Purified by immunoaffinity chromatography.
Form/Format
Supplied as a liquid in PBSN3, before the addition of glycerol to 40%. Conjugated to KLH.
Immunogen
Synthetic peptide (HGQPQPPHQQPL-C) of human FOXD3. MW: 47.63kD.
Preparation and Storage
May be stored at 4 degree C for short-term only. For long-term storage, aliquot and store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Other Notes
Small volumes of anti-FOXD3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Product Categories/Family for anti-FOXD3 antibody
Antibodies; Abs to Transcription Factors
Applications Tested/Suitable for anti-FOXD3 antibody
ELISA (EL/EIA)
Application Notes for anti-FOXD3 antibody
Suitable for use in ELISA.
Dilution: ELISA Titer: 1:250,000
NCBI/Uniprot data below describe general gene information for FOXD3. It may not necessarily be applicable to this product.
NCBI Accession #
NP_036315.1
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NCBI GenBank Nucleotide #
NM_012183.2
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UniProt Primary Accession #
Q9UJU5
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UniProt Secondary Accession #
Q9BYM2; Q9UDD1[Other Products]
UniProt Related Accession #
Q9UJU5[Other Products]
Molecular Weight
47,630 Da[Similar Products]
NCBI Official Full Name
forkhead box protein D3
NCBI Official Synonym Full Names
forkhead box D3
NCBI Official Symbol
FOXD3 [Similar Products]
NCBI Official Synonym Symbols
AIS1; HFH2; Genesis
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NCBI Protein Information
forkhead box protein D3; OTTHUMP00000010713; HNF3/FH transcription factor genesis
UniProt Protein Name
Forkhead box protein D3
UniProt Synonym Protein Names
HNF3/FH transcription factor genesis
Protein Family
Forkhead box protein
UniProt Gene Name
FOXD3 [Similar Products]
UniProt Synonym Gene Names
HFH2 [Similar Products]
UniProt Entry Name
FOXD3_HUMAN
NCBI Summary for FOXD3
This gene belongs to the forkhead family of transcription factors which is characterized by a distinct forkhead domain. Mutations in this gene cause autoimmune susceptibility 1. [provided by RefSeq]
UniProt Comments for FOXD3
FOXD3: Binds to the consensus sequence 5'-A[AT]T[AG]TTTGTTT-3' and acts as a transcriptional repressor. Also acts as a transcriptional activator. Promotes development of neural crest cells from neural tube progenitors. Restricts neural progenitor cells to the neural crest lineage while suppressing interneuron differentiation. Required for maintenance of pluripotent cells in the pre-implantation and peri-implantation stages of embryogenesis. Expressed in chronic myeloid leukemia, Jurkat T-cell leukemia and teratocarcinoma cell lines, but not in any other cell lines or normal tissues examined.
Protein type: DNA-binding
Chromosomal Location of Human Ortholog: 1p31.3
Cellular Component: nucleoplasm; nuclear chromatin
Molecular Function: protein binding; double-stranded DNA binding; transcription factor activity
Biological Process: embryonic placenta development; transcription, DNA-dependent; in utero embryonic development; somatic stem cell maintenance; positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription from RNA polymerase II promoter; trophectodermal cell differentiation
Disease: Autoimmune Disease, Susceptibility To, 1
Research Articles on FOXD3
1. Studies show FOXD3 is suppressed by B-RAF, uncover a novel role and mechanism for FOXD3 as a negative cell cycle regulator, and have implications for the repression of melanocytic lineage cells.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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