Full Product Name
FOXD3 Antibody
Product Synonym Names
AIS1; HFH2; Genesis; FOXD3
Product Gene Name
anti-FOXD3 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q9UJU5
Species Reactivity
Human, Mouse, Monkey
Form/Format
Ascitic fluid containing 0.03% sodium azide.
Immunogen
Purified recombinant fragment of human FOXD3 expressed in E. Coli.
Preparation and Storage
Store at 4 degree C, for long term storage, store at-20 degree C.
Other Notes
Small volumes of anti-FOXD3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-FOXD3 antibody
FoxD3 is a member of the Forkhead Box family and is characterized by a winged-helix DNA-binding structure and the important role it plays in embryonic development. This transcriptional regulator is required for the maintenance of pluripotency in the pre-implantation and peri-implantation stages of mouse embryonic development and is also required for trophoblast formation. FoxD3 is required for the maintenance of the mammalian neural crest; FoxD3(-/-) mouse embryos fail around the time of implantation with loss of neural crest-derived structures. FoxD3 also forms a regulatory network with Oct-4 and NANOG to maintain the pluripotency of ES cells.Promotes development of neural crest cells from neural tube progenitors. Restricts neural progenitor cells to the neural crest lineage while suppressing interneuron differentiation. Required for maintenance of pluripotent cells in the pre-implantation and peri-implantation stages of embryogenesis. Tissue specificity: Expressed in chronic myeloid leukemia, Jurkat T-cell leukemia and teratocarcinoma cell lines, but not in any other cell lines or normal tissues examined.
Product Categories/Family for anti-FOXD3 antibody
Autophagy antibody; Cancer; Cardiovascular; Cell Biology; Epigenetics & Nuclear Signaling; Developmental Biologys; Immunology; Drug Discovery Products; Metabolism; Neuroscience; Signal Transduction; Stem Cells
Applications Tested/Suitable for anti-FOXD3 antibody
Western Blot (WB), ELISA (EIA)
Application Notes for anti-FOXD3 antibody
WB: 1:500-1:2000
ELISA: 1:10000
Western Blot (WB) of anti-FOXD3 antibody
Figure 1: Western blot analysis using FOXD3 mouse mAb against NTERA-1 (1), HUVE-12 (2), HEK293 (3), Hela (4), Jurkat (5), NIH/3T3 (6), K562 (7), RAW264.7 (8) and COS7 (9) cell lysate.
NCBI/Uniprot data below describe general gene information for FOXD3. It may not necessarily be applicable to this product.
NCBI Accession #
NP_036315.1
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NCBI GenBank Nucleotide #
NM_012183.2
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UniProt Primary Accession #
Q9UJU5
[Other Products]
UniProt Secondary Accession #
Q9BYM2; Q9UDD1[Other Products]
UniProt Related Accession #
Q9UJU5[Other Products]
NCBI Official Full Name
forkhead box protein D3
NCBI Official Synonym Full Names
forkhead box D3
NCBI Official Symbol
FOXD3 [Similar Products]
NCBI Official Synonym Symbols
AIS1; HFH2; VAMAS2; Genesis
[Similar Products]
NCBI Protein Information
forkhead box protein D3
UniProt Protein Name
Forkhead box protein D3
UniProt Synonym Protein Names
HNF3/FH transcription factor genesis
Protein Family
Forkhead box protein
UniProt Gene Name
FOXD3 [Similar Products]
UniProt Synonym Gene Names
HFH2 [Similar Products]
NCBI Summary for FOXD3
This gene belongs to the forkhead family of transcription factors which is characterized by a distinct forkhead domain. Mutations in this gene cause autoimmune susceptibility 1. [provided by RefSeq, Nov 2008]
UniProt Comments for FOXD3
Binds to the consensus sequence 5'-A[AT]T[AG]TTTGTTT-3' and acts as a transcriptional repressor. Also acts as a transcriptional activator. Promotes development of neural crest cells from neural tube progenitors. Restricts neural progenitor cells to the neural crest lineage while suppressing interneuron differentiation. Required for maintenance of pluripotent cells in the pre-implantation and peri-implantation stages of embryogenesis.
Research Articles on FOXD3
1. FOXD3 knockdown resulted in enhanced ATC proliferation, invasion and migration and diminished cellular apoptosis. Further, we showed that FOXD3 regulated expression of E-cadherin by modulating MAPK/EKR signaling pathway that promotes EMT and metastasis during thyroid carcinogenesis.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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