Full Product Name
ITSN2 Antibody, HRP conjugated
Product Synonym Names
Intersectin-2; SH3 domain-containing protein 1B; SH3P18; SH3P18-like WASP-associated protein; ITSN2; KIAA1256; SH3D1B; SWAP
Product Gene Name
anti-ITSN2 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q9NZM3
Purity/Purification
>95%, Protein G purified
Immunogen
Recombinant Human Intersectin-2 protein (940-1209AA)
Preservative
0.03% Proclin 300
Constituents
50% Glycerol, 0.01M PBS, PH 7.4
Santa Cruz Alternative
Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-9952 / sc-9953 / sc-9954 / sc-9955
Preparation and Storage
Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of anti-ITSN2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-ITSN2 antibody
Adapter protein that may provide indirect link between the endocytic membrane traffic and the actin assembly machinery. May regulate the formation of clathrin-coated vesicles (CCPs). Seems to be involved in CCPs maturation including invagination or budding. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR). Plays a role in dendrite formation by melanocytes (PubMed: 23999003).
Applications Tested/Suitable for anti-ITSN2 antibody
ELISA (EIA)
NCBI/Uniprot data below describe general gene information for ITSN2. It may not necessarily be applicable to this product.
NCBI Accession #
NP_006268.2
[Other Products]
NCBI GenBank Nucleotide #
NM_006277.2
[Other Products]
UniProt Primary Accession #
Q9NZM3
[Other Products]
UniProt Secondary Accession #
O95062; Q15812; Q9HAK4; Q9NXE6; Q9NYG0; Q9NZM2; Q9ULG4[Other Products]
UniProt Related Accession #
Q9NZM3[Other Products]
Molecular Weight
135,144 Da
NCBI Official Full Name
intersectin-2 isoform 1
NCBI Official Synonym Full Names
intersectin 2
NCBI Official Symbol
ITSN2 [Similar Products]
NCBI Official Synonym Symbols
SWA; SWAP; SH3D1B; SH3P18; PRO2015
[Similar Products]
NCBI Protein Information
intersectin-2
UniProt Protein Name
Intersectin-2
UniProt Synonym Protein Names
SH3 domain-containing protein 1B; SH3P18; SH3P18-like WASP-associated protein
Protein Family
Intersectin
UniProt Gene Name
ITSN2 [Similar Products]
UniProt Synonym Gene Names
KIAA1256; SH3D1B; SWAP [Similar Products]
UniProt Entry Name
ITSN2_HUMAN
NCBI Summary for ITSN2
This gene encodes a cytoplasmic protein which contains SH3 domains. This protein is a member of a family of proteins involved in clathrin-mediated endocytosis. Intersectin 2 is thought to regulate the formation of clathrin-coated vesicles and also may function in the induction of T cell antigen receptor (TCR) endocytosis. [provided by RefSeq, Jan 2017]
UniProt Comments for ITSN2
ITSN2: adapter protein that contains SH3 domains. Involved in the formation of clathrin-coated vesicles. May function in the induction of T cell antigen receptor (TCR) endocytosis. May provide indirect link between the endocytic membrane traffic and the actin assembly machinery. Three alternatively spliced isoforms have been described.
Protein type: Adaptor/scaffold
Chromosomal Location of Human Ortholog: 2p23.3
Cellular Component: centrosome
Molecular Function: protein binding; SH3/SH2 adaptor activity
Research Articles on ITSN2
1. ITSN2L interacts with RABEP1 and stimulates its degradation in regulation of endocytosis.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
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