Fermitin family homolog 1, ELISA Kit

Fermitin family homolog 1; Kindlin-1; Unc-112-related protein 1; Fermt1; Kind1; Urp1

For Research Use Only. Not for use in diagnostic procedures.

Store at 4 degree C

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Small volumes of Fermt1 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS9427295 is a ready-to-use microwell, strip-or-full plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Fermitin family homolog 1 (Fermt1) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing Fermt1. The ELISA analytical biochemical technique of the MBS9427295 kit is based on Fermt1 antibody-Fermt1 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect Fermt1 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, Fermt1. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).

76,941 Da

fermitin family member 1

fermitin family homolog 1

Fermitin family homolog 1

Kind1; Urp1  [Similar Products]

kindlin-1: Involved in cell adhesion. Contributes to integrin activation. When coexpressed with talin, potentiates activation of ITGA2B. Required for normal keratinocyte proliferation. Required for normal polarization of basal keratinocytes in skin, and for normal cell shape. Required for normal adhesion of keratinocytes to fibronectin and laminin, and for normal keratinocyte migration to wound sites. May mediate TGF-beta 1 signaling in tumor progression. Defects in FERMT1 are the cause of Kindler syndrome (KINDS). An autosomal recessive skin disorder characterized by skin blistering, photosensitivity, progressive poikiloderma, and extensive skin atrophy. Additional clinical features include gingival erosions, ocular, esophageal, gastrointestinal and urogenital involvement, and an increased risk of mucocutaneous malignancy. Although most FERMT1 mutations are predicted to lead to premature termination of translation, and to loss of FERMT1 function, significant clinical variability is observed among patients. There is an association of FERMT1 missense and in-frame deletion mutations with milder disease phenotypes, and later onset of complications (PubMed:21936020). Belongs to the kindlin family. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Cytoskeletal; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 2|2 F2

Cellular Component: cell junction; cytosol; filamentous actin; focal adhesion

Biological Process: cell adhesion; keratinocyte migration; keratinocyte proliferation; negative regulation of anagen; negative regulation of protein import into nucleus; positive regulation of cell adhesion mediated by integrin; positive regulation of cell-matrix adhesion; positive regulation of transforming growth factor beta receptor signaling pathway

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