Product Name
Torsin 1A (TOR1A), Polyclonal Antibody
Full Product Name
Biotin-Linked Polyclonal Antibody to Torsin 1A (TOR1A)
Product Synonym Names
DQ2; DYT1; TORA; Torsin A; Dystonia 1; Torsin ATPase-1A; Torsin family 1 member A
Product Gene Name
anti-TOR1A antibody
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Matching Pairs
Unconjugated Antibody: Torsin 1A (MBS2026184)
Biotin Conjugated Antibody: Torsin 1A (TOR1A) (MBS2096239)
Matching Pairs
Biotin Conjugated Antibody: Torsin 1A (TOR1A) (MBS2096239)
Immunogen: Torsin 1A (MBS2030643)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q9ER39
Concentration
200ug/ml (lot specific)
Immunogen
TOR1A (Val33~Thr321)
ISO Certification
Manufactured in an ISO 9001:2008 and ISO 13485:2003 Certified Laboratory.
Supply Chain Verification
Manufactured in a lab with traceable raw materials. Bulk orders can typically be prepared to the customerâs specifications, please inquire.
Other Notes
Small volumes of anti-TOR1A antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-TOR1A antibody
Western Blot (WB), Immunohistochemistry (IHC)
NCBI/Uniprot data below describe general gene information for TOR1A. It may not necessarily be applicable to this product.
NCBI Accession #
NP_659133.1
[Other Products]
NCBI GenBank Nucleotide #
NM_144884.2
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UniProt Primary Accession #
Q9ER39
[Other Products]
UniProt Related Accession #
Q9ER39[Other Products]
Molecular Weight
37,830 Da
NCBI Official Full Name
torsin-1A
NCBI Official Synonym Full Names
torsin family 1, member A (torsin A)
NCBI Official Symbol
Tor1a [Similar Products]
NCBI Official Synonym Symbols
DQ2; Dyt1; torsinA
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NCBI Protein Information
torsin-1A
UniProt Protein Name
Torsin-1A
UniProt Synonym Protein Names
Dystonia 1 protein; Torsin ATPase 1 (EC:3.6.4.-); Torsin family 1 member A
UniProt Gene Name
Tor1a [Similar Products]
UniProt Synonym Gene Names
Dyt1 [Similar Products]
UniProt Comments for TOR1A
TOR1A: May serve as a molecular chaperone assisting in the proper folding of secreted and/or membrane proteins. In the nucleus, displaces the nuclear membrane proteins SUN2, SYNE2 and nesprin-3/C14orf49, leaving nuclear pores and SUN1 unchanged. May form homohexamers. Interacts with TOR1AIP1 and TOR1AIP2. Interacts with KLHL14, preferentially when ATP-free. Widely expressed. Highest levels in kidney and liver. Not detected in spleen. In the brain, high levels found in the dopaminergic neurons of the substantia nigra pars compacta, as well as in the neocortex, hippocampus and cerebellum. Also high expression in the spinal cord. Belongs to the clpA/clpB family. Torsin subfamily. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 2|2 B
Cellular Component: cell junction; cell projection; cytoplasm; cytoplasmic vesicle; cytoplasmic vesicle membrane; cytoskeleton; endoplasmic reticulum; endoplasmic reticulum lumen; growth cone; intracellular membrane-bound organelle; membrane; neuron projection; nuclear envelope; nuclear membrane; nucleus; secretory granule; synapse; synaptic vesicle
Molecular Function: ATP binding; ATPase activity; cytoskeletal protein binding; hydrolase activity; kinesin binding; misfolded protein binding; nucleotide binding; protein binding; unfolded protein binding
Biological Process: cell adhesion; chaperone cofactor-dependent protein folding; intermediate filament cytoskeleton organization and biogenesis; neuron projection development; nuclear envelope organization; organelle organization and biogenesis; protein deneddylation; protein homooligomerization; regulation of dopamine uptake; response to oxidative stress; synaptic vesicle transport
Research Articles on TOR1A
1. Purkinje cells (PC) express high levels of TA also in the spines and axonal terminals. In addition, abundant expression of the protein was found in the main GABA-ergic and glutamatergic inputs of the cerebellar cortex. Finally, TA was observed also in glial cells, a cellular population little explored so far. These results extend our knowledge on TA synaptic localization providing a clue to its potential role in synaptic
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Disclaimer
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