Full Product Name
PHX2A Polyclonal Antibody
Product Synonym Names
Paired mesoderm homeobox protein 2A; ARIX1 homeodomain protein; Aristaless homeobox protein homolog; Paired-like homeobox 2A; PHOX2A; ARIX; PMX2A
Product Gene Name
anti-PHX2A antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for O14813
Species Reactivity
Human, Mouse, Rat
Purity/Purification
Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Form/Format
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Immunogen
Synthesized peptide derived from human protein. at AA range: 210-290
Preparation and Storage
Store at-20 degree C for 1 year.
Other Notes
Small volumes of anti-PHX2A antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Applications Tested/Suitable for anti-PHX2A antibody
Western Blot (WB), ELISA (EIA)
Application Notes for anti-PHX2A antibody
WB: 1:500-2000
ELISA: 1:5000-20000
NCBI/Uniprot data below describe general gene information for PHX2A. It may not necessarily be applicable to this product.
NCBI Accession #
NP_005160.2
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NCBI GenBank Nucleotide #
NM_005169.3
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UniProt Primary Accession #
O14813
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UniProt Secondary Accession #
Q8IVZ2; A8K3N0[Other Products]
UniProt Related Accession #
O14813[Other Products]
NCBI Official Full Name
paired mesoderm homeobox protein 2A
NCBI Official Synonym Full Names
paired like homeobox 2a
NCBI Official Symbol
PHOX2A [Similar Products]
NCBI Official Synonym Symbols
ARIX; FEOM2; NCAM2; PMX2A; CFEOM2
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NCBI Protein Information
paired mesoderm homeobox protein 2A
UniProt Protein Name
Paired mesoderm homeobox protein 2A
UniProt Synonym Protein Names
ARIX1 homeodomain protein; Aristaless homeobox protein homolog; Paired-like homeobox 2A
UniProt Gene Name
PHOX2A [Similar Products]
UniProt Synonym Gene Names
ARIX; PMX2A [Similar Products]
NCBI Summary for PHX2A
The protein encoded by this gene contains a paired-like homeodomain most similar to that of the Drosophila aristaless gene product. The encoded protein plays a central role in development of the autonomic nervous system. It regulates the expression of tyrosine hydroxylase and dopamine beta-hydroxylase, two catecholaminergic biosynthetic enzymes essential for the differentiation and maintenance of the noradrenergic neurotransmitter phenotype. The encoded protein has also been shown to regulate transcription of the alpha3 nicotinic acetylcholine receptor gene. Mutations in this gene have been associated with autosomal recessive congenital fibrosis of the extraocular muscles. [provided by RefSeq, Jul 2008]
UniProt Comments for PHX2A
May be involved in regulating the specificity of expression of the catecholamine biosynthetic genes. Acts as a transcription activator/factor. Could maintain the noradrenergic phenotype.
Research Articles on PHX2A
1. PHOX2A expression is finely controlled during retinoic acid differentiation and this, together with PHOX2B down-regulation.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
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