Product Name
Involucrin (IVL), Blocking Peptide
Full Product Name
Involucrin Blocking Peptide
Product Synonym Names
Involucrin
Product Gene Name
IVL blocking peptide
[Similar Products]
Involucrin peptide (MBS822701) is used for blocking the activity of Involucrin antibody (MBS820782)
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for P07476
Species Reactivity
Human, Mouse, Rat
Form/Format
Lyophilized powder
Quality Control
The quality of the peptide was evaluated by reversed-phase HPLC and by mass spectrometry.
Preparation and Storage
Shipped at 4 degree C. Store at -20 degree C for one year.
Other Notes
Small volumes of IVL blocking peptide vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
IVL blocking peptide
The peptide is used to block Anti-Involucrin Antibody reactivity.
Applications Tested/Suitable for IVL blocking peptide
Blocking (BL)
Application Notes for IVL blocking peptide
Blocking Peptide to the diluted primary antibody in a molar ratio of 10:1 (peptide to antibody) and incubate the mixture at 4 degree C for overnight or at room temperature for 2 hours.
NCBI/Uniprot data below describe general gene information for IVL. It may not necessarily be applicable to this product.
NCBI Accession #
NP_005538.2
[Other Products]
NCBI GenBank Nucleotide #
NM_005547.2
[Other Products]
UniProt Primary Accession #
P07476
[Other Products]
UniProt Secondary Accession #
Q5T7P4[Other Products]
UniProt Related Accession #
P07476[Other Products]
Molecular Weight
68,479 Da
NCBI Official Full Name
involucrin
NCBI Official Synonym Full Names
involucrin
NCBI Official Symbol
IVL [Similar Products]
NCBI Protein Information
involucrin
UniProt Protein Name
Involucrin
Protein Family
Involucrin
UniProt Gene Name
IVL [Similar Products]
UniProt Entry Name
INVO_HUMAN
NCBI Summary for IVL
Involucrin, a component of the keratinocyte crosslinked envelope, is found in the cytoplasm and crosslinked to membrane proteins by transglutaminase. This gene is mapped to 1q21, among calpactin I light chain, trichohyalin, profillaggrin, loricrin, and calcyclin. [provided by RefSeq, Jul 2008]
UniProt Comments for IVL
IVL: Part of the insoluble cornified cell envelope (CE) of stratified squamous epithelia. Belongs to the involucrin family.
Chromosomal Location of Human Ortholog: 1q21
Cellular Component: cytoplasm; cornified envelope
Molecular Function: protein binding, bridging; structural molecule activity
Biological Process: keratinocyte differentiation; isopeptide cross-linking via N6-(L-isoglutamyl)-L-lysine; keratinization; peptide cross-linking; response to UV-B
Research Articles on IVL
1. over-expression of Nnat was evident along with involucrin and cytokeratin1 expression
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
