Orexin Receptor-2 (N Terminal), Polyclonal Antibody

Ox2r; Hypocretin receptor type 2

For Research Use Only. Not for use in diagnostic procedures.

Chromosome: 6; NC_000006.11 (55039071..55147418). Location: 6p12

Polyclonal

IgG

Rabbit

Antigen Immunoaffiinity Purification

Affinity purified polyclonal antibody provided as solution in phosphate buffered saline with 0.08% sodium azide

Product should be stored at -20 degree C. Aliquot to avoid freeze/thaw cycles

Small volumes of anti-HCRTR2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

As first published in 1998 by Sakurai et al,, the initial neuropeptides Orexin A and Orexin B were shown to be important in the regulation of appetite. Continued research now suggests that these peptides also influence a wide range of physiological and behavioral processes such as increased EFG arousal and wakefulness and locomotor activity. In addition to the orexins, two G-protein coupled receptors, designated orexin receptor-1 and orexin receptor-2, have been identified which presumably mediate the signaling events from these neuropeptides1. Recently orexin receptors have been found to activate extracellular signal-regulated kinases in CHO cells, namely ERK phosporylation, through Ca2+ influx..2. Further studies seem to indicate a mechanism for orexin receptor mediated cell death and suggest a pathway from GPCR?s to apoptosis throughthe MAPK pathways.3

Antigen Immunoaffinity Purified Polyclonal; Neuronal Signaling

ELISA (EIA)

50.6[Similar Products]

hypocretin (orexin) receptor 2

orexin receptor type 2; ox2-R; ox-2-R; hypocretin receptor type 2

Orexin receptor type 2

Ox-2-R; Ox2-R; Ox2R  [Similar Products]

OX2R_HUMAN

The protein encoded by this gene is a G-protein coupled receptor involved in the regulation of feeding behavior. The encoded protein binds the hypothalamic neuropeptides orexin A and orexin B. A related gene (HCRTR1) encodes a G-protein coupled receptor that selectively binds orexin A. [provided by RefSeq, Jan 2009]

Function: Nonselective, high-affinity receptor for both orexin-A and orexin-B neuropeptides.

Subcellular location: Cell membrane; Multi-pass membrane protein.

Sequence similarities: Belongs to the G-protein coupled receptor 1 family.

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