Full Product Name
ASPM Antibody, HRP conjugated
Product Synonym Names
Abnormal spindle-like microcephaly-associated protein; Abnormal spindle protein homolog; Asp homolog; ASPM; MCPH5
Product Gene Name
anti-ASPM antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q8IZT6
Purity/Purification
>95%, Protein G purified
Immunogen
Recombinant Human Abnormal spindle-like microcephaly-associated protein (101-234AA)
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Preparation and Storage
Upon receipt, store at -20 degree C or -80 degree C. Avoid repeated freeze.
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Other Notes
Small volumes of anti-ASPM antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-ASPM antibody
Probable role in mitotic spindle regulation and coordination of mitotic processes. May have a preferential role in regulating neurogenesis.
Product Categories/Family for anti-ASPM antibody
Others
Applications Tested/Suitable for anti-ASPM antibody
ELISA (EIA)
NCBI/Uniprot data below describe general gene information for ASPM. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001193775.1
[Other Products]
NCBI GenBank Nucleotide #
NM_001206846.1
[Other Products]
UniProt Primary Accession #
Q8IZT6
[Other Products]
UniProt Secondary Accession #
Q4G1H1; Q5VYL3; Q86UX4; Q8IUL2; Q8IZJ7; Q8IZJ8; Q8IZJ9; Q8N4D1; Q9NVS1; Q9NVT6[Other Products]
UniProt Related Accession #
Q8IZT6[Other Products]
Molecular Weight
217,794 Da
NCBI Official Full Name
abnormal spindle-like microcephaly-associated protein isoform 2
NCBI Official Synonym Full Names
abnormal spindle microtubule assembly
NCBI Official Symbol
ASPM [Similar Products]
NCBI Official Synonym Symbols
ASP; MCPH5; Calmbp1
[Similar Products]
NCBI Protein Information
abnormal spindle-like microcephaly-associated protein
UniProt Protein Name
Abnormal spindle-like microcephaly-associated protein
UniProt Synonym Protein Names
Abnormal spindle protein homolog; Asp homolog
Protein Family
Abnormal spindle-like microcephaly-associated protein
UniProt Gene Name
ASPM [Similar Products]
UniProt Synonym Gene Names
MCPH5; Asp homolog [Similar Products]
NCBI Summary for ASPM
This gene is the human ortholog of the Drosophila melanogaster 'abnormal spindle' gene (asp), which is essential for normal mitotic spindle function in embryonic neuroblasts. Studies in mouse also suggest a role of this gene in mitotic spindle regulation, with a preferential role in regulating neurogenesis. Mutations in this gene are associated with microcephaly primary type 5. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, May 2011]
UniProt Comments for ASPM
Involved in mitotic spindle regulation and coordination of mitotic processes. The function in regulating microtubule dynamics at spindle poles including spindle orientation, astral microtubule density and poleward microtubule flux seems to depend on the association with the katanin complex formed by KATNA1 and KATNB1. Enhances the microtubule lattice severing activity of KATNA1 by recruiting the katanin complex to microtubules. Can block microtubule minus-end growth and reversely this function can be enhanced by the katanin complex (PubMed:28436967). May have a preferential role in regulating neurogenesis.
Research Articles on ASPM
1. Abnormal cortical development in primary microcephaly was recapitulated with organoid culture in vitro using patient's induced pluripotent stem cells with ASPM mutation.
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
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