Product Name
Desmoglein 1 (DSG1), Polyclonal Antibody
Full Product Name
Anti-Desmoglein 1 Antibody
Product Synonym Names
CDHF4; Desmoglein-1; Cadherin family member 4; Desmosomal glycoprotein 1; DG1; DGI; Pemphigus foliaceus antigen
Product Gene Name
anti-DSG1 antibody
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Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q02413
Species Reactivity
Human, Mouse, Rat
Specificity
Recognizes endogenous levels of Desmoglein 1 protein.
Purity/Purification
Purified by immunogen affinity chromatography.
Form/Format
Liquid in 0.42% Potassium Phosphate, 0.87% Sodium Chloride, pH 7.3, 30% Glycerol, and 0.01% Sodium Azide.
Immunogen
KLH-conjugated synthetic peptide encompassing a sequence within the center region of human Desmoglein 1.
Preparation and Storage
Upon delivery aliquot and store at-20 degree C for one year. Avoid freeze/thaw cycles.
Other Notes
Small volumes of anti-DSG1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-DSG1 antibody
Rabbit polyclonal antibody to Desmoglein 1
Applications Tested/Suitable for anti-DSG1 antibody
Western Blot (WB)
Application Notes for anti-DSG1 antibody
WB: 1:500-1:1000
Western Blot (WB) of anti-DSG1 antibody
Western blot analysis of Desmoglein 1 expression in Beas2B (A), H9C2 (B), MEF (C) whole cell lysates.
NCBI/Uniprot data below describe general gene information for DSG1. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001933.2
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NCBI GenBank Nucleotide #
NM_001942.3
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UniProt Primary Accession #
Q02413
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UniProt Secondary Accession #
B7Z845[Other Products]
UniProt Related Accession #
Q02413[Other Products]
Molecular Weight
42,619 Da
NCBI Official Full Name
desmoglein-1 preproprotein
NCBI Official Synonym Full Names
desmoglein 1
NCBI Official Symbol
DSG1 [Similar Products]
NCBI Official Synonym Symbols
DG1; DSG; CDHF4; EPKHE; PPKS1; SPPK1; EPKHIA
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NCBI Protein Information
desmoglein-1
UniProt Protein Name
Desmoglein-1
UniProt Synonym Protein Names
Cadherin family member 4; Desmosomal glycoprotein 1; DG1; DGI; Pemphigus foliaceus antigen
Protein Family
Desmoglein
UniProt Gene Name
DSG1 [Similar Products]
UniProt Synonym Gene Names
CDHF4; DG1; DGI [Similar Products]
NCBI Summary for DSG1
This gene encodes a member of the desmoglein protein subfamily. Desmogleins, along with desmocollins, are cadherin-like transmembrane glycoproteins that are major components of the desmosome. Desmosomes are cell-cell junctions that help resist shearing forces and are found in high concentrations in cells subject to mechanical stress. This gene is found in a cluster with other desmoglein family members on chromosome 18. The encoded protein has been identified as a target of auto-antibodies in the autoimmune skin blistering disease pemphigus foliaceus. Disruption of this gene has also been associated with the skin diseases palmoplantar keratoderma and erythroderma. [provided by RefSeq, Feb 2015]
UniProt Comments for DSG1
Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.
Research Articles on DSG1
1. Here the authors identify a potential mechanism by which desmosomes assist the de-neddylating COP9 signalosome (CSN) in attenuating EGFR through an association between the Cops3 subunit of the CSN and desmosomal components, Desmoglein1 (Dsg1) and Desmoplakin (Dp), to promote epidermal differentiation.
Precautions
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Disclaimer
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