Product Name
Kynureninase, Polyclonal Antibody
Full Product Name
Anti-Kynureninase Antibody
Product Synonym Names
Kynureninase; L-kynurenine hydrolase
Product Gene Name
anti-KYNU antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
3D Structure
ModBase 3D Structure for Q16719
Specificity
Recognizes endogenous levels of Kynureninase protein.
Purity/Purification
The antibody was purified by immunogen affinity chromatography.
Form/Format
Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.
Immunogen
Recombinant full length protein of human Kynureninase
Preparation and Storage
Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C for one year. Avoid freeze/thaw cycles.
Other Notes
Small volumes of anti-KYNU antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-KYNU antibody
Rabbit polyclonal antibody to Kynureninase
Applications Tested/Suitable for anti-KYNU antibody
Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-KYNU antibody
WB: 1/500 - 1/2000; IHC: 1/50 - 1/200
Western Blot (WB) of anti-KYNU antibody
Western blot analysis of Kynureninase expression in A549 (A), HepG2 (B), mouse spleen (C) whole cell lysates.
Immunohistochemistry (IHC) of anti-KYNU antibody
Immunohistochemical analysis of Kynureninase staining in mouse heart formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX.
NCBI/Uniprot data below describe general gene information for KYNU. It may not necessarily be applicable to this product.
NCBI Accession #
NP_001028170.1
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NCBI GenBank Nucleotide #
NM_001032998.1
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UniProt Primary Accession #
Q16719
[Other Products]
UniProt Secondary Accession #
Q6I9T2; Q9BVW3; B2RCZ5; D3DP79[Other Products]
UniProt Related Accession #
Q16719[Other Products]
Molecular Weight
34,635 Da
NCBI Official Full Name
kynureninase isoform b
NCBI Official Synonym Full Names
kynureninase
NCBI Official Symbol
KYNU [Similar Products]
NCBI Official Synonym Symbols
KYNUU
[Similar Products]
NCBI Protein Information
kynureninase
UniProt Protein Name
Kynureninase
UniProt Synonym Protein Names
L-kynurenine hydrolase
Protein Family
Kynureninase
UniProt Gene Name
KYNU [Similar Products]
UniProt Entry Name
KYNU_HUMAN
NCBI Summary for KYNU
Kynureninase is a pyridoxal-5'-phosphate (pyridoxal-P) dependent enzyme that catalyzes the cleavage of L-kynurenine and L-3-hydroxykynurenine into anthranilic and 3-hydroxyanthranilic acids, respectively. Kynureninase is involved in the biosynthesis of NAD cofactors from tryptophan through the kynurenine pathway. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2010]
UniProt Comments for KYNU
KYNU: Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively. Has a preference for the L-3-hydroxy form. Also has cysteine-conjugate-beta-lyase activity. Xanthurenic aciduria manifesting as massive urinary excretion of large amounts of kynurenine, 3-hydroxykynurenine and xanthurenic acid has been observed in an individual carrying a homozygous missense change in KYNU (PubMed:17334708). The urinary pattern in the patient suggests kynureninase deficiency and a block in the conversion of kynurenine and 3-hydroxykynurenine to anthranilate and 3-hydroxyanthranilate, respectively. Belongs to the kynureninase family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Mitochondrial; Hydrolase; Amino Acid Metabolism - tryptophan; EC 3.7.1.3
Chromosomal Location of Human Ortholog: 2q22.2
Cellular Component: cytoplasm; cytosol; mitochondrion; nucleoplasm
Molecular Function: kynureninase activity; protein homodimerization activity; pyridoxal phosphate binding
Biological Process: anthranilate metabolic process; quinolinate biosynthetic process; tryptophan catabolic process; tryptophan catabolic process to acetyl-CoA; tryptophan catabolic process to kynurenine
Disease: Hydroxykynureninuria
Research Articles on KYNU
1. A rare variant at the KYNU gene is associated with essential hypertension in the Han Chinese population.
Precautions
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