Full Product Name
FBP2, CT (Fructose-1,6-bisphosphatase Isozyme 2, FBPase 2, D-fructose-1,6-bisphosphate 1-phosphohydrolase 2)
Product Synonym Names
Anti -FBP2, CT (Fructose-1,6-bisphosphatase Isozyme 2, FBPase 2, D-fructose-1,6-bisphosphate 1-phosphohydrolase 2)
Product Gene Name
anti-FBP2 antibody
[Similar Products]
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
Chromosome Location
Chromosome: 9; NC_000009.11 (97321002..97356075, complement). Location: 9q22.3
3D Structure
ModBase 3D Structure for O00757
Species Reactivity
Human, Mouse
Specificity
Recognizes human FBP2. Species Crossreactivity: mouse.
Purity/Purification
Purified
Purified by ammonium sulfate precipitation.
Form/Format
Supplied as a liquid in PBS, 0.09% sodium azide.
Immunogen
Synthetic peptide selected from the C-terminal region of human FBP2 (KLH).
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Other Notes
Small volumes of anti-FBP2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-FBP2 antibody
FBP2 is a gluconeogenesis regulatory enzyme which catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate and inorganic phosphate.
Product Categories/Family for anti-FBP2 antibody
Antibodies; Abs to Enzymes, Phosphatase
Applications Tested/Suitable for anti-FBP2 antibody
ELISA (EL/EIA), Western Blot (WB)
Application Notes for anti-FBP2 antibody
Suitable for use in ELISA and Western Blot.
Dilution: ELISA: 1:1,000
Western Blot: 1:50-1:100
NCBI/Uniprot data below describe general gene information for FBP2. It may not necessarily be applicable to this product.
UniProt Primary Accession #
O00757
[Other Products]
UniProt Secondary Accession #
Q17R39; Q6FI53[Other Products]
UniProt Related Accession #
O00757; Q9UJ73; Q9UMQ9; Q9UMR0[Other Products]
Molecular Weight
36,743 Da[Similar Products]
NCBI Official Full Name
FBP2
NCBI Official Synonym Full Names
fructose-1,6-bisphosphatase 2
NCBI Official Symbol
FBP2 [Similar Products]
NCBI Official Synonym Symbols
MGC142192
[Similar Products]
NCBI Protein Information
fructose-1,6-bisphosphatase isozyme 2; FBPase 2; OTTHUMP00000021696; hexosediphosphatase; muscle fructose-bisphosphatase; D-fructose-1,6-bisphosphate 1-phosphohydrolase 2
UniProt Protein Name
Fructose-1,6-bisphosphatase isozyme 2
UniProt Synonym Protein Names
D-fructose-1,6-bisphosphate 1-phosphohydrolase 2
Protein Family
Fat body protein
UniProt Gene Name
FBP2 [Similar Products]
UniProt Entry Name
F16P2_HUMAN
NCBI Summary for FBP2
This gene encodes a gluconeogenesis regulatory enzyme which catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate and inorganic phosphate. [provided by RefSeq]
UniProt Comments for FBP2
FBPase 2: a key enzyme of gluconeogenesis that catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate, a precursor to glucose 6-phosphate. A regulator of glucose synthesis from non-carbohydrates. Two paralogs of this enzyme exists in humans: FBP1 is expressed in the liver and gluconeogenic tissues, and FBP2 in striated muscle. FBP2 is only isozyme expressed in striated muscle and it is widely expressed in cells that are nongluconeogenic. Both forms are inhibited allosterically by AMP, NAD and Ca2+. The muscle form is about 100-fold more sensitive to AMP and NAD, and about 1000-fold more sensitive to inhibition by Ca2+, the major activator of glycolysis in striated muscle. Forms an active complex with aldolase that binds to the sarcomeric Z-line, which is disrupted by elevated calcium levels, blocking glycogen synthesis during exercise. Forms homotetramers that are stabilized in the active state by divalent cations (Mg2+, Mn2+ , Co+2, or Zn2+). Its interaction with aldolase appears to desensitizes it to inhibition by AMP and, partially, by Ca2+. Up to 50% of lactate generated in striated muscle is converted to glycogen.
Protein type: Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - pentose phosphate pathway; EC 3.1.3.11; Carbohydrate Metabolism - fructose and mannose; Phosphatase (non-protein)
Chromosomal Location of Human Ortholog: 9q22.3
Cellular Component: Z disc; cytosol; cell junction; nucleus
Molecular Function: metal ion binding; fructose-bisphosphatase activity
Biological Process: dephosphorylation; carbohydrate metabolic process; glucose metabolic process; pathogenesis; fructose metabolic process; gluconeogenesis
Research Articles on FBP2
1. Observational study of gene-disease association. (HuGE Navigator)
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
